Journal article
Age-Associated Differences in Central Artery Responsiveness to Sympathoexcitatory Stimuli
American journal of hypertension, Vol.32(6), pp.564-569
05/09/2019
DOI: 10.1093/ajh/hpz035
PMID: 30854541
Abstract
BACKGROUND Age-associated arterial stiffening may be the result of greater tonic sympathetic nerve activity. However, age-associated changes in central artery responsiveness to sympathoexcitatory stimuli are understudied. Therefore, we examined changes in central artery stiffness and wave reflection in response to sympathoexcitatory stimuli in young and older adults. METHODS Fourteen young (25 ± 4 years) and 15 older (68 ± 4 years) subjects completed 3 minutes of the cold pressor test (CPT) and lower-body negative pressure (LBNP) separated by 15 minutes. Carotid–femoral pulse wave velocity (cfPWV), central augmentation pressure (cAP), and augmentation index (AIx) were measured in duplicate during rest and the final minute of each perturbation. RESULTS Young subjects had lower baseline cfPWV, cAP, and AIx than older subjects (P < 0.05 for all). During the CPT mean arterial pressure (MAP), cfPWV, cAP, and AIx increased in both groups (P < 0.05 for all); however, changes (Δ) in MAP (18 ± 7 vs. 9 ± 5 mm Hg), cfPWV (1.3 ± 0.7 vs. 0.6 ± 0.9 m/s), cAP (4 ± 2 vs. 6 ± 3 mm Hg), and AIx (18 ± 9% vs. 7 ± 4%) were greater in young vs. older subjects, respectively (P < 0.05 for all). With MAP as a covariate, cfPWV, cAP, and AIx responses to the CPT were no longer significantly different between groups. During LBNP, changes in MAP (–1 ± 3 vs. –3 ± 5 mm Hg), cfPWV (0.5 ± 0.3 vs. 0.5 ± 0.7 m/s), cAP (–2 ± 2 vs. –2 ± 3 mm Hg), and AIx (–7 ± 7% vs. –3 ± 6%) were similar between young and older groups, respectively (P > 0.05 for all). CONCLUSIONS Collectively, our data suggest the sympathetic nervous system may directly modulate central hemodynamics and that age-associated differences in central artery responsiveness to sympathoexcitatory stimuli are largely attributable to differential blood pressure responses.
Details
- Title: Subtitle
- Age-Associated Differences in Central Artery Responsiveness to Sympathoexcitatory Stimuli
- Creators
- Joshua M Bock - University of IowaWilliam E Hughes - University of IowaDarren P Casey - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.32(6), pp.564-569
- DOI
- 10.1093/ajh/hpz035
- PMID
- 30854541
- NLM abbreviation
- Am J Hypertens
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 05/09/2019
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984294955502771
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