Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin

Jordan L Schultz; Ellen van der Plas; Douglas R Langbehn; Amy L Conrad; Peg C Nopoulos

doi:10.1002/ana.26039

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Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin

Journal article

Peer reviewed

Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin

Jordan L Schultz, Ellen van der Plas, Douglas R Langbehn, Amy L Conrad and Peg C Nopoulos

Annals of neurology, Vol.89(5), pp.1036-1040

05/2021

DOI: 10.1002/ana.26039

PMCID: PMC8176779

PMID: 33521985

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Abstract

Limited data exists regarding the disease course of Huntington's Disease (HD) in children and young adults. Here, we evaluate the trajectory of various cognitive skill development as a function of cytosine-adenine-guanine (CAG) repeat length in children and adolescents that carry the mutation that causes HD. We discovered that the development of verbal skills seems to plateau earlier as CAG repeat length increases. These findings increase our understanding of the relationship between neurodegeneration and neurodevelopment and may have far-reaching implications for future gene-therapy treatment strategies. ANN NEUROL 2021;89:1036-1040.

Details

Title: Subtitle: Age-Related Cognitive Changes as a Function of CAG Repeat in Child and Adolescent Carriers of Mutant Huntingtin
Creators: Jordan L Schultz - Department of Pharmacy Practice and Sciences, University of Iowa College of Pharmacy, Iowa City, IA, USA
Ellen van der Plas - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Douglas R Langbehn - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Amy L Conrad - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Peg C Nopoulos - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Annals of neurology, Vol.89(5), pp.1036-1040
DOI: 10.1002/ana.26039
PMID: 33521985
PMCID: PMC8176779
NLM abbreviation: Ann Neurol
ISSN: 0364-5134
eISSN: 1531-8249
Publisher: United States
Grant note: R01NS055903 / NINDS NIH HHS
Language: English
Date published: 05/2021
Academic Unit: Neurology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Pharmacy Practice and Science
Record Identifier: 9984066138702771

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