Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts

Carlos H Martinez; Alejandro A Diaz; Amit D Parulekar; Stephen I Rennard; Richard E Kanner; Nadia N Hansel; David Couper; Kristen E Holm; Karin F Hoth; Jeffrey L Curtis; Fernando J Martinez; Nicola A Hanania; Elizabeth A Regan; Robert Paine III; Christine T Cigolle; MeiLan K Han; COPDGene and SPIROMICS Investigators

doi:10.1016/j.chest.2015.11.025

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Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts

Journal article

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Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts

Carlos H Martinez, Alejandro A Diaz, Amit D Parulekar, Stephen I Rennard, Richard E Kanner, Nadia N Hansel, David Couper, Kristen E Holm, Karin F Hoth, Jeffrey L Curtis, …

Chest, Vol.149(4), pp.927-935

04/2016

DOI: 10.1016/j.chest.2015.11.025

PMCID: PMC4944781

PMID: 26836895

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Abstract

Younger persons with COPD report worse health-related quality of life (HRQL) than do older individuals. The factors explaining these differences remain unclear. The objective of this article was to explore factors associated with age-related differences in HRQL in COPD. Cross-sectional analysis of participants with COPD, any Global Initiative for Chronic Obstructive Lung Disease grade of airflow limitation, and ≥ 50 years old in two cohorts: the Genetic Epidemiology of COPD (COPDGene) study and the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). We compared St. George's Respiratory Questionnaire (SGRQ) scores by age group: middle-aged (age, 50-64) vs older (age, 65-80) adults. We used multivariate linear modeling to test associations of age with HRQL, adjusting for demographic and clinical characteristics and comorbidities. Among 4,097 participants in the COPDGene study (2,170 middle-aged and 1,927 older adults) SGRQ total scores were higher (worse) among middle-aged (mean difference, -4.2 points; 95% CI, -5.7 to -2.6; P < .001) than older adults. Age had a statistically significant interaction with dyspnea (P < .001). Greater dyspnea severity (modified Medical Research Council ≥ 2, compared with 0-1) had a stronger association with SGRQ score among middle-aged (β, 24.6; 95% CI, 23.2-25.9) than older-adult (β, 21.0; 95% CI, 19.6-22.3) participants. In analyses using SGRQ as outcome in 1,522 participants in SPIROMICS (598 middle-aged and 924 older adults), we found similar associations, confirming that for the same severity of dyspnea there is a stronger association with HRQL among younger individuals. Age-related differences in HRQL may be explained by a higher impact of dyspnea among younger subjects with COPD. ClinicalTrials.gov; No.: NCT00608764 and No.: NCT01969344; URL: www.clinicaltrials.gov.

Quality of Life

Age Factors

Cross-Sectional Studies

Humans

Middle Aged

Female

Male

Aged

Dyspnea - physiopathology

Pulmonary Disease, Chronic Obstructive - physiopathology

Health Status

Cohort Studies

Details

Title: Subtitle: Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts
Creators: Carlos H Martinez - Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI. Electronic address: carlosma@umich.edu
Alejandro A Diaz - Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Amit D Parulekar - Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX
Stephen I Rennard - Division of Pulmonary and Critical Care Medicine, University of Nebraska, Omaha, NE
Richard E Kanner - University of Utah, Salt Lake City, UT
Nadia N Hansel - Johns Hopkins University, Baltimore, MD
David Couper - University of North Carolina at Chapel Hill, Chapel Hill, NC
Kristen E Holm - National Jewish Health, Denver, CO; School of Public Health, University of Colorado, Aurora, CO
Karin F Hoth - Department of Psychiatry, University of Iowa, Iowa City, IA
Jeffrey L Curtis - Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI; VA Ann Arbor Healthcare System, Ann Arbor, MI
Fernando J Martinez - Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI
Nicola A Hanania - Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX
Elizabeth A Regan - National Jewish Health, Denver, CO; University of Colorado, Denver, CO
Robert Paine III - University of Utah, Salt Lake City, UT; VA Salt Lake City, Salt Lake City, UT
Christine T Cigolle - Department of Family Medicine, University of Michigan, Ann Arbor, MI; VA Ann Arbor Healthcare System, Ann Arbor, MI
MeiLan K Han - Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI
COPDGene and SPIROMICS Investigators
Resource Type: Journal article
Publication Details: Chest, Vol.149(4), pp.927-935
DOI: 10.1016/j.chest.2015.11.025
PMID: 26836895
PMCID: PMC4944781
NLM abbreviation: Chest
ISSN: 0012-3692
eISSN: 1931-3543
Publisher: United States
Grant note: HHSN268200900017C / NHLBI NIH HHS K01 HL118714 / NHLBI NIH HHS HHSN268200900019C / NHLBI NIH HHS HHSN268200900020C / NHLBI NIH HHS K23 HL095658 / NHLBI NIH HHS R01 HL089856 / NHLBI NIH HHS HHSN268200900015C / NHLBI NIH HHS K01HL118714 / NHLBI NIH HHS HHSN268200900013C / NHLBI NIH HHS R01 HL122438 / NHLBI NIH HHS HHSN268200900016C / NHLBI NIH HHS 3R01HL122438-02S1 / NHLBI NIH HHS K23 HL128936 / NHLBI NIH HHS HHSN268200900018C / NHLBI NIH HHS HHSN268200900014C / NHLBI NIH HHS HHSN268200900009C / WHI NIH HHS R01 HL089897 / NHLBI NIH HHS K08 AG031837 / NIA NIH HHS
Language: English
Date published: 04/2016
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003931802771

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