Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Giuseppe De Luca; Magdy Algowhary; Berat Uguz; Dinaldo C Oliveira; Vladimir Ganyukov; Oliver Busljetik; Miha Cercek; Lisette Okkels Jensen; Poay Huan Loh; Lucian Calmac; Alexandre Quadros; Gerard Roura I Ferrer; Marek Milewski; Fortunato Scotto D'Uccio; Clemens von Birgelen; Francesco Versaci; Jurrien Ten Berg; Gianni Casella; Aaron Wong Sung Lung; Petr Kala; José Luis Díez Gil; Xavier Carrillo; Maurits Dirksen; Victor Becerra Munoz; Michael Kang-Yin Lee; Dafsah Arifa Juzar; Rodrigo de Moura Joaquim; Roberto Paladino; Davor Milicic; Periklis Davlouros; Nikola Bakraceski; Filippo Zilio; Luca Donazzan; Adriaan Kraaijeveld; Gennaro Galasso; Lux Arpad; Lucia Marinucci; Vincenzo Guiducci; Maurizio Menichelli; Alessandra Scoccia; Aylin Hatice Yamac; Kadir Ugur Mert; Xacobe Flores Rios; Tomas Kovarnik; Michal Kidawa; Josè Moreu; Vincent Flavien; Enrico Fabris; Iñigo Lozano Martínez-Luengas; Marco Boccalatte; Francisco Bosa Ojeda; Carlos Arellano-Serrano; Gianluca Caiazzo; Giuseppe Cirrincione; Hsien-Li Kao; Juan Sanchis Forés; Luigi Vignali; Helder Pereira; Stephane Manzo-Silberman; Santiago Ordoñez; Alev Arat Özkan; Bruno Scheller; Heidi Lehitola; Rui Teles; Christos Mantis; Ylitalo Antti; João António Brum Silveira; Cesar Rodrigo Zoni; Ivan Bessonov; Giuseppe Uccello; George Kochiadakis; Dimitrios Alexopulos; Carlos E Uribe; John Kanakakis; Benjamin Faurie; Gabriele Gabrielli; Alejandro Gutierrez Barrios; Juan Pablo Bachini; Alex Rocha; Frankie C C Tam; Alfredo Rodriguez; Antonia Anna Lukito; Veauthyelau Saint-Joy; Gustavo Pessah; Andrea Tuccillo; Alfonso Ielasi; Giuliana Cortese; Guido Parodi; Mohammed Abed Burgadha; Elvin Kedhi; Pablo Lamelas; Harry Suryapranata; Matteo Nardin; Monica Verdoia

doi:10.3390/jcm12062116

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Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

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Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C Oliveira, Vladimir Ganyukov, Oliver Busljetik, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, …

Journal of clinical medicine, Vol.12(6), p.2116

03/01/2023

DOI: 10.3390/jcm12062116

PMCID: PMC10059932

PMID: 36983119

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Abstract

The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, < 0.0001). We found a significant age-related reduction (7%, = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.

COVID-19

ageing

ST-segment elevation myocardial infarction

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Title: Subtitle: Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
Creators: Giuseppe De Luca - Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Magdy Algowhary - Assiut University
Berat Uguz - Bursa Technical University
Dinaldo C Oliveira - Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife 1235, Brazil
Vladimir Ganyukov - Kemerovo State University
Oliver Busljetik - Saints Cyril and Methodius University of Skopje
Miha Cercek - Ljubljana University Medical Centre
Lisette Okkels Jensen - Odense University Hospital
Poay Huan Loh - National University Hospital
Lucian Calmac - Clinical Emergency Hospital Bucharest
Alexandre Quadros - Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90000-00, Brazil
Gerard Roura I Ferrer - Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, 08016 Barcelona, Spain
Marek Milewski - Medical University of Silesia
Fortunato Scotto D'Uccio - Division of Cardiology, Ospedale del Mare, 80147 Napoli, Italy
Clemens von Birgelen - Medisch Spectrum Twente
Francesco Versaci - Ospedale Santa Maria Goretti
Jurrien Ten Berg - Division of Cardiology, St Antonius Hospital, 3434 Nieuwegein, The Netherlands
Gianni Casella - Ospedale Maggiore Carlo Alberto Pizzardi
Aaron Wong Sung Lung - Department of Cardiology, National Heart Center, Singapore 169609, Singapore
Petr Kala - Masaryk University
José Luis Díez Gil - Cardiology, H. Universitario y Politécnico La Fe, 46001 Valencia, Spain
Xavier Carrillo - Hospital Universitari Germans Trias i Pujol
Maurits Dirksen - Northwest Hospital
Victor Becerra Munoz - Hospital Clínico Universitario Virgen de la Victoria
Michael Kang-Yin Lee - Queen Elizabeth Hospital
Dafsah Arifa Juzar - University of Indonesia
Rodrigo de Moura Joaquim - Instituto de Cardiologia de Santa Catarina
Roberto Paladino - Division of Cardiology, Clinica Villa dei Fiori, 80011 Acerra, Italy
Davor Milicic - University Hospital Centre Zagreb
Periklis Davlouros - General University Hospital of Patras
Nikola Bakraceski - Center for Cardiovascular Diseases, 6000 Ohrid, North Macedonia
Filippo Zilio - Ospedale Santa Chiara
Luca Donazzan - Ospedale di Bolzano
Adriaan Kraaijeveld - University Medical Center Utrecht
Gennaro Galasso - Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
Lux Arpad - Maastricht University
Lucia Marinucci - Ospedali Riuniti Marche Nord
Vincenzo Guiducci - Azienda Sanitaria Unità Locale di Reggio Emilia
Maurizio Menichelli - Division of Cardiology, Ospedale "F. Spaziani", 03100 Frosinone, Italy
Alessandra Scoccia - Ospedale Sant'Anna
Aylin Hatice Yamac - Bezmiâlem Vakıf Üniversitesi
Kadir Ugur Mert - Eskişehir Osmangazi University
Xacobe Flores Rios - Complexo Hospetaliero Universitario La Coruna, 15001 La Coruna, Spain
Tomas Kovarnik - General University Hospital in Prague
Michal Kidawa - Medical University of Lodz
Josè Moreu - Complejo Hospitalario Universitario de Toledo
Vincent Flavien - Division of Cardiology, Center Hospitalier Universitaire de Lille, 59000 Lille, France
Enrico Fabris - Azienda Sanitaria Universitaria Integrata di Trieste
Iñigo Lozano Martínez-Luengas - Hospital de Cabueñes
Marco Boccalatte - Ospedale Santa Maria
Francisco Bosa Ojeda - Hospital Universitario de Canarias
Carlos Arellano-Serrano - Hospital Universitario Puerta de Hierro Majadahonda
Gianluca Caiazzo - Azienda Ospedaliera S.Giuseppe Moscati
Giuseppe Cirrincione - Azienda di Rilievo Nazionale ed Alta Specializzazione
Hsien-Li Kao - National Taiwan University Hospital
Juan Sanchis Forés - Hospital Clínico Universitario de Valencia
Luigi Vignali - Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, 43121 Parma, Italy
Helder Pereira - Hospital Garcia de Orta
Stephane Manzo-Silberman - Assistance Publique – Hôpitaux de Paris
Santiago Ordoñez - Instituto Cardiovascular de Buenos Aires
Alev Arat Özkan - Cardiology Institute, Instanbul University, 34000 Istanbul, Türkiye
Bruno Scheller - Saarland University
Heidi Lehitola - Oulu University Hospital
Rui Teles - Hospital de Santa Cruz
Christos Mantis - Agia Olga Hospital
Ylitalo Antti - Turku PET Centre
João António Brum Silveira - Hospital de Santo António
Cesar Rodrigo Zoni - Department of Teaching and Research, Instituto de Cardiología de Corrientes "Juana F. Cabral", Corrientes W3400CDS, Argentina
Ivan Bessonov - Tyumen Cardiology Research Center, 625026 Tyumen, Russia
Giuseppe Uccello - Alessandro Manzoni Hospital
George Kochiadakis - University Hospital of Heraklion
Dimitrios Alexopulos - University General Hospital Attikon
Carlos E Uribe - Clínica CES
John Kanakakis - Alexandra Hospital
Benjamin Faurie - Groupe Hospitalier Mutualiste de Grenoble
Gabriele Gabrielli - Istituto Nazionale di Riposo e Cura per Anziani
Alejandro Gutierrez Barrios - Division of Cardiology, Hospital Puerta del Mar, 11001 Cadiz, Spain
Juan Pablo Bachini - Instituto de Cardiologia Integral, Montevideo 11700, Uruguay
Alex Rocha - Instituto Nacional de Investigación Agropecuaria
Frankie C C Tam - Queen Mary Hospital
Alfredo Rodriguez - Sanatorio Otamendi y Miroli
Antonia Anna Lukito - Pelita Harapan University
Veauthyelau Saint-Joy - Center Hospitalierd'Antibes Juan Les Pins, 06600 Antibes, France
Gustavo Pessah - Servicio Diabetología Hospital Córdoba
Andrea Tuccillo - Division of Cardiology, Ospedale del Mare, 80147 Napoli, Italy
Alfonso Ielasi - Istituto Clinico Sant'Ambrogio
Giuliana Cortese - University of Padua
Guido Parodi - Azienda Unità Sanitaria Locale Della Romagna
Mohammed Abed Burgadha - University of Blida
Elvin Kedhi - Université Libre de Bruxelles
Pablo Lamelas - Instituto Cardiovascular de Buenos Aires
Harry Suryapranata - Radboud University Nijmegen
Matteo Nardin - Department of Internal Medicine, Ospedale Riuniti, 25121 Brescia, Italy
Monica Verdoia - Ospedale degli Infermi
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.12(6), p.2116
DOI: 10.3390/jcm12062116
PMID: 36983119
PMCID: PMC10059932
ISSN: 2077-0383
eISSN: 2077-0383
Language: English
Date published: 03/01/2023
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984627339402771

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