Journal article
Age-Related Variations in Takotsubo Syndrome
Journal of the American College of Cardiology, Vol.75(16), pp.1869-1877
04/28/2020
DOI: 10.1016/j.jacc.2020.02.057
PMID: 32327096
Abstract
Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.
This study aimed to investigate age-related differences in TTS.
Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups.
Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups.
A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.
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Details
- Title: Subtitle
- Age-Related Variations in Takotsubo Syndrome
- Creators
- Victoria L. Cammann - University of ZurichKonrad A. Szawan - University of ZurichBarbara E. Stähli - University of ZurichKen Kato - University of ZurichMonika Budnik - Medical University of WarsawManfred Wischnewsky - University of BremenSara Dreiding - University of ZurichRena A. Levinson - University of ZurichDavide Di Vece - University of ZurichSebastiano Gili - Centro cardiologico Monzino, IRCCS, Milan, ItalyRodolfo Citro - Heart Department, University Hospital “San Giovanni di Dio e Ruggi d'Aragona,” Salerno, ItalyEduardo Bossone - Division of Cardiology, “Antonio Cardarelli” Hospital, Naples, ItalyMichael Neuhaus - Department of Cardiology, Kantonsspital Frauenfeld, Frauenfeld, SwitzerlandJennifer Franke - University Hospital HeidelbergBenjamin Meder - University Hospital HeidelbergMiłosz Jaguszewski - First Department of Cardiology, Medical University of Gdansk, Gdansk, PolandMichel Noutsias - Martin Luther University Halle-WittenbergMaike Knorr - Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, GermanySusanne Heiner - Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, GermanyFabrizio D’Ascenzo - Division of Cardiology, Department of Medical Sciences, AOU Città della Salute e della Scienza, University of Turin, Turin, ItalyWolfgang Dichtl - University Hospital for Internal Medicine III (Cardiology and Angiology), Medical University Innsbruck, Innsbruck, AustriaChristof Burgdorf - Heart and Vascular Centre Bad Bevensen, Bad Bevensen, GermanyBehrouz Kherad - Charité - University Medicine BerlinCarsten Tschöpe - Charité - University Medicine BerlinAnnahita Sarcon - University of California, San FranciscoJerold Shinbane - University of Southern CaliforniaLawrence Rajan - HealthPartnersGuido Michels - University of CologneRoman Pfister - University of CologneAlessandro Cuneo - Krankenhaus “Maria Hilf” Medizinische Klinik, Stadtlohn, GermanyClaudius Jacobshagen - University of GöttingenMahir Karakas - Kiel UniversityWolfgang Koenig - Technical University of MunichAlexander Pott - University of UlmPhilippe Meyer - Service de cardiologie, Hôpitaux Universitaires de Genève, Geneva, SwitzerlandMarco Roffi - Service de cardiologie, Hôpitaux Universitaires de Genève, Geneva, SwitzerlandAdrian Banning - John Radcliffe HospitalMathias Wolfrum - Otto-von-Guericke University MagdeburgFlorim Cuculi - Department of Cardiology, Kantonsspital Lucerne, Lucerne, SwitzerlandRichard Kobza - Department of Cardiology, Kantonsspital Lucerne, Lucerne, SwitzerlandThomas A. Fischer - Winterthur Museum Garden and LibraryTuija Vasankari - Turku University HospitalK.E. Juhani Airaksinen - Turku University HospitalL. Christian Napp - Hannover Medical SchoolRafal Dworakowski - University of CambridgePhilip MacCarthy - University of CambridgeChristoph Kaiser - University Hospital of BaselStefan Osswald - University Hospital of BaselLeonarda Galiuto - Catholic University of the Sacred HeartChristina Chan - Christchurch HospitalPaul Bridgman - Christchurch HospitalDaniel Beug - Greifswald University HospitalClément Delmas - Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, FranceOlivier Lairez - Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, FranceEkaterina Gilyarova - Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, RussiaAlexandra Shilova - Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, RussiaMikhail Gilyarov - Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, RussiaIbrahim El-Battrawy - Heidelberg UniversityIbrahim Akin - Heidelberg UniversityKarolina Poledniková - Charles UniversityPetr Toušek - Charles UniversityDavid E. Winchester - University of FloridaJan Galuszka - Department of Internal Medicine I - Cardiology, University Hospital Olomouc, Olomouc, Czech RepublicChristian Ukena - Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyGregor Poglajen - Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana, Ljubljana, SloveniaPedro Carrilho-Ferreira - University of LisbonChristian Hauck - University Hospital RegensburgCarla Paolini - Local Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, ItalyClaudio Bilato - Local Health Unit n.8, Cardiology Unit, Arzignano, Vicenza, ItalyYoshio Kobayashi - Chiba UniversityToshihiro Shoji - Department of Cardiology, Chiba Emergency Medical Center, Chiba, JapanIwao Ishibashi - Department of Cardiology, Chiba Emergency Medical Center, Chiba, JapanMasayuki Takahara - Division of Cardiology, Kimitsu Central Hospital, Kisarazu, JapanToshiharu Himi - Division of Cardiology, Kimitsu Central Hospital, Kisarazu, JapanJehangir Din - Royal Bournemouth HospitalAli Al-Shammari - Royal Bournemouth HospitalAbhiram Prasad - Mayo ClinicCharanjit S. Rihal - Mayo ClinicKan Liu - University of IowaP. Christian Schulze - Friedrich Schiller University JenaMatteo Bianco - Division of Cardiology, A.O.U San Luigi Gonzaga, Orbassano, Turin, ItalyLucas Jörg - Kantonsspital St. GallenHans Rickli - Kantonsspital St. GallenGonçalo Pestana - Department of Cardiology, Centro Hospitalar Universitário de São João, E.P.E., Porto, PortugalThanh H. Nguyen - University of AdelaideMichael Böhm - Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, GermanyLars S. Maier - University Hospital RegensburgFausto J. Pinto - University of LisbonPetr Widimský - Charles UniversityStephan B. Felix - Greifswald University HospitalRuediger C. Braun-Dullaeus - Otto-von-Guericke University MagdeburgWolfgang Rottbauer - University of UlmGerd Hasenfuß - University of GöttingenBurkert M. Pieske - Charité - University Medicine BerlinHeribert Schunkert - University Hospital RegensburgMartin Borggrefe - Heidelberg UniversityHolger Thiele - Leipzig UniversityJohann Bauersachs - Medizinische Hochschule HannoverHugo A. Katus - University Hospital HeidelbergJohn D. Horowitz - University of AdelaideCarlo Di Mario - Structural Interventional Cardiology, Careggi University Hospital, Florence, ItalyThomas Münzel - Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, GermanyFilippo Crea - Catholic University of the Sacred HeartJeroen J. Bax - Leiden UniversityThomas F. Lüscher - Imperial College LondonFrank Ruschitzka - University of ZurichJelena R. Ghadri - University of ZurichGrzegorz Opolski - Medical University of WarsawChristian Templin - University of Zurich
- Resource Type
- Journal article
- Publication Details
- Journal of the American College of Cardiology, Vol.75(16), pp.1869-1877
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jacc.2020.02.057
- PMID
- 32327096
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Grant note
- name: TTS
- Language
- English
- Date published
- 04/28/2020
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318692802771
Metrics
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