Age and Sex Influence Cystatin C in Adolescents With and Without Type 1 Diabetes

David M Maahs; Nicole Prentice; Kim McFann; Janet K Snell-Bergeon; Diana Jalal; Franziska K Bishop; Brittany Aragon; R. Paul Wadwa

doi:10.2337/dc11-0829

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Age and Sex Influence Cystatin C in Adolescents With and Without Type 1 Diabetes

Journal article

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Age and Sex Influence Cystatin C in Adolescents With and Without Type 1 Diabetes

David M Maahs, Nicole Prentice, Kim McFann, Janet K Snell-Bergeon, Diana Jalal, Franziska K Bishop, Brittany Aragon and R. Paul Wadwa

Diabetes care, Vol.34(11), pp.2360-2362

11/2011

DOI: 10.2337/dc11-0829

PMCID: PMC3198267

PMID: 21926294

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Abstract

Objective: To compare serum cystatin C levels, a novel biomarker of renal function, in adolescents with and without type 1 diabetes and to determine what factors affect cystatin C levels. Research design and methods: Cystatin C was measured in youth 12-19 years of age with (n = 259, diabetes duration 9 ± 3 years, HbA(1c) 8.9 ± 1.6%) and without diabetes (n = 78). Data were compared by diabetes status, and linear regression was used to determine factors affecting cystatin C. Results: Cystatin C (0.698 ± 0.083 vs. 0.688 ± 0.127 mg/L, P = 0.40) was similar by diabetes status. In multiple linear regression, cystatin C was associated with age and serum creatinine in nondiabetic subjects and sex, age, and serum creatinine in subjects with diabetes (P < 0.05). Conclusions: These data suggest sex differences and age-related changes in cystatin C in adolescents with type 1 diabetes. An understanding of these changes is needed to determine the potential role of cystatin C as a marker of renal function in this population.

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Title: Subtitle: Age and Sex Influence Cystatin C in Adolescents With and Without Type 1 Diabetes
Creators: David M Maahs - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
Nicole Prentice - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
Kim McFann - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
Janet K Snell-Bergeon - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
Diana Jalal - Department of Medicine, Division of Nephrology, University of Colorado Denver, Aurora, Colorado
Franziska K Bishop - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
Brittany Aragon - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
R. Paul Wadwa - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
Resource Type: Journal article
Publication Details: Diabetes care, Vol.34(11), pp.2360-2362
DOI: 10.2337/dc11-0829
PMID: 21926294
PMCID: PMC3198267
NLM abbreviation: Diabetes Care
ISSN: 0149-5992
eISSN: 1935-5548
Publisher: American Diabetes Association
Language: English
Date published: 11/2011
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094659202771

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