Journal article
Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS
American journal of respiratory and critical care medicine, Vol.195(4), pp.464-472
02/15/2017
DOI: 10.1164/rccm.201604-0871OC
PMCID: PMC5378423
PMID: 27564413
Abstract
Aging is associated with reduced FEV
to FVC ratio (FEV
/FVC), hyperinflation, and alveolar enlargement, but little is known about how age affects small airways.
To determine if chest computed tomography (CT)-assessed functional small airway would increase with age, even among asymptomatic individuals.
We used parametric response mapping analysis of paired inspiratory/expiratory CTs to identify functional small airway abnormality (PRM
) and emphysema (PRM
) in the SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study) cohort. Using adjusted linear regression models, we analyzed associations between PRM
and age in subjects with or without airflow obstruction. We subdivided participants with normal spirometry based on respiratory-related impairment (6-minute-walk distance <350 m, modified Medical Research Council ≥2, chronic bronchitis, St. George's Respiratory Questionnaire >25, respiratory events requiring treatment [antibiotics and/or steroids or hospitalization] in the year before enrollment).
Among 580 never- and ever-smokers without obstruction or respiratory impairment, PRM
increased 2.7% per decade, ranging from 3.6% (ages 40-50 yr) to 12.7% (ages 70-80 yr). PRM
increased nonsignificantly (0.1% [ages 40-50 yr] to 0.4% [ages 70-80 yr]; P = 0.34). Associations were similar among nonobstructed individuals with respiratory-related impairment. Increasing PRM
in subjects without airflow obstruction was associated with increased FVC (P = 0.004) but unchanged FEV
(P = 0.94), yielding lower FEV
/FVC ratios (P < 0.001). Although emphysema was also significantly associated with lower FEV
/FVC (P = 0.04), its contribution relative to PRM
in those without airflow obstruction was limited by its low burden.
In never- and ever-smokers without airflow obstruction, aging is associated with increased FVC and CT-defined functional small airway abnormality regardless of respiratory symptoms.
Details
- Title: Subtitle
- Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS
- Creators
- Carlos H Martinez - 1 Division of Pulmonary and Critical Care MedicineAlejandro A Diaz - 2 Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsCatherine Meldrum - 1 Division of Pulmonary and Critical Care MedicineJeffrey L Curtis - 3 Pulmonary and Critical Care Medicine Section, Medical Service, andChristopher B Cooper - 4 Division of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, CaliforniaCheryl Pirozzi - 5 Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UtahRichard E Kanner - 5 Division of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UtahRobert Paine III - 6 Division of Pulmonary and Critical Care Medicine, Veterans Affairs Medical Center, Salt Lake City, UtahPrescott G Woodruff - 7 Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CaliforniaEugene R Bleecker - 8 Division of Pulmonary and Critical Care Medicine, Wake Forest University, Winston-Salem, North CarolinaNadia N Hansel - 9 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MarylandR Graham Barr - 10 Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, New YorkNathaniel Marchetti - 11 Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PennsylvaniaGerard J Criner - 11 Department of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PennsylvaniaElla A Kazerooni - 12 Department of Radiology, andEric A Hoffman - 13 Department of Radiology and Biomedical Engineering, University of Iowa, Iowa City, Iowa; andBrian D Ross - 14 Center for Molecular Imaging, University of Michigan, Ann Arbor, MichiganCraig J Galban - 14 Center for Molecular Imaging, University of Michigan, Ann Arbor, MichiganChristine T Cigolle - 15 Department of Family Medicine, University of Michigan Health System, Ann Arbor, MichiganFernando J Martinez - 1 Division of Pulmonary and Critical Care MedicineMeiLan K Han - 1 Division of Pulmonary and Critical Care Medicine
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.195(4), pp.464-472
- DOI
- 10.1164/rccm.201604-0871OC
- PMID
- 27564413
- PMCID
- PMC5378423
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- United States
- Grant note
- K01 HL118714 / NHLBI NIH HHS HHSN268200900019C / NHLBI NIH HHS HHSN268200900020C / NHLBI NIH HHS HHSN268200900015C / NHLBI NIH HHS I01 CX000911 / CSRD VA R01 HL122438 / NHLBI NIH HHS R01 HL130883 / NHLBI NIH HHS U01 HL089856 / NHLBI NIH HHS HHSN268200900018C / NHLBI NIH HHS HHSN268200900014C / NHLBI NIH HHS HHSN268200900009C / WHI NIH HHS P01 CA085878 / NCI NIH HHS HHSN268200900017C / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS U01 HL089897 / NHLBI NIH HHS U01 HL137880 / NHLBI NIH HHS R01 HL089856 / NHLBI NIH HHS HHSN268200900013C / NHLBI NIH HHS P30 CA086862 / NCI NIH HHS HHSN268200900016C / NHLBI NIH HHS K23 HL128936 / NHLBI NIH HHS S10 OD018526 / NIH HHS T32 HL007749 / NHLBI NIH HHS R44 HL118837 / NHLBI NIH HHS R01 HL089897 / NHLBI NIH HHS K08 AG031837 / NIA NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 02/15/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051778502771
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