Journal article
Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases
American journal of respiratory and critical care medicine, Vol.202(7), pp.1013-1023
10/01/2020
DOI: 10.1164/rccm.201911-2151OC
PMCID: PMC7528799
PMID: 32501729
Abstract
A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases. Because depletion of these cells might be valuable in patients with certain lung diseases, the goal was to find out if ABC-like cells were at elevated levels in such patients.
To measure ABC-like cell percentages in patients with lung granulomatous diseases.
Peripheral blood and BAL cells from patients with sarcoidosis, beryllium sensitivity, or hypersensitivity pneumonitis and healthy subjects were analyzed for the percentage of B cells that were ABC-like, defined by expression of CD11c, low levels of CD21, FcRL 1-5 (Fc receptor-like protein 1-5) expression, and, in some cases, T-bet.
ABC-like cells in blood were at low percentages in healthy subjects and higher percentages in patients with sarcoidosis as well as at high percentages among BAL cells of patients with sarcoidosis, beryllium disease, and hypersensitivity pneumonitis. Treatment of patients with sarcoidosis led to reduced percentages of ABC-like cells in blood.
Increased levels of ABC-like cells in patients with sarcoidosis may be useful in diagnosis. The increase in percentage of ABC-like cells in patients with lung granulomatous diseases and decrease in treated patients suggests that depletion of these cells may be valuable.
Details
- Title: Subtitle
- Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases
- Creators
- Swati Phalke - Department of Biomedical Research.Katja Aviszus - Department of Biomedical Research.Kira Rubtsova - Department of Biomedical Research.Anatoly Rubtsov - Department of Biomedical Research.Briana Barkes - Department of Medicine, and.Linda Powers - University of IowaBrenda Warner - Roy J. and Lucille A. Carver College of MedicineJames L Crooks - Colorado School of Public HealthJohn W Kappler - University of Colorado Anschutz Medical CampusEvans R Fernández-Pérez - Department of Medicine, and.Lisa A Maier - Department of Medicine, and.Nabeel Hamzeh - Roy J. and Lucille A. Carver College of MedicinePhilippa Marrack - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.202(7), pp.1013-1023
- DOI
- 10.1164/rccm.201911-2151OC
- PMID
- 32501729
- PMCID
- PMC7528799
- ISSN
- 1535-4970
- eISSN
- 1535-4970
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984360045702771
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