Journal article
Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis
Cell reports (Cambridge), Vol.43(3), 113967
03/15/2024
DOI: 10.1016/j.celrep.2024.113967
PMCID: PMC11014686
PMID: 38492219
Abstract
Non-canonical lipolysis induced by inflammatory cytokines or Toll-like receptor ligands is required for the regulation of inflammation during endotoxemia and sepsis. Canonical lipolysis induced by catecholamines declines during aging due to factors including an expansion of lymphocytes, pro-inflammatory macrophage polarization, and an increase in chronic low-grade inflammation; however, the extent to which the non-canonical pathway of lipolysis is active and impacted by immune cells during aging remains unclear. Therefore, we aimed to define the extent to which immune cells from old mice influence non-canonical lipolysis during sepsis. We identified age-associated impairments of non-canonical lipolysis and an accumulation of dysfunctional B1 B cells in the visceral white adipose tissue (vWAT) of old mice. Lifelong deficiency of B cells results in restored non-canonical lipolysis and reductions in pro-inflammatory macrophage populations. Our study suggests that targeting the B cell-macrophage signaling axis may resolve metabolic dysfunction in aged vWAT and attenuate septic severity in older individuals.
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•Non-canonical lipolysis induced by sepsis and LPS is impaired in vWAT from old mice•vWAT accumulates B1 B cells with reduced sepsis-induced activation during aging•Old vWAT B1 and B2 B cells have inflammatory transcriptional responses to LPS•Lifelong B cell KO increases non-canonical lipolysis and reduces macrophage inflammation
Carey et al. demonstrate that inflammation is increased but lipolysis is reduced following sepsis or endotoxemia in old mice. They identify an accumulation of inflammatory B1 B cells and B2 B cells in the visceral white adipose tissue (vWAT) of old mice. They find that B cells promote pro-inflammatory macrophages and impair non-canonical vWAT lipolysis.
Details
- Title: Subtitle
- Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis
- Creators
- Anna Carey - University of MinnesotaKatie Nguyen - University of MinnesotaPranathi Kandikonda - University of MinnesotaVictor Kruglov - University of MinnesotaClaire Bradley - University of MinnesotaKorbyn J.V. Dahlquist - University of MinnesotaStephanie Cholensky - University of MinnesotaWhitney Swanson - University of MinnesotaVladimir P. Badovinac - University of IowaThomas S. Griffith - University of MinnesotaChristina D. Camell - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.43(3), 113967
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.celrep.2024.113967
- PMID
- 38492219
- PMCID
- PMC11014686
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Grant note
- DOI: 10.13039/100000049, name: National Institute on Aging; DOI: 10.13039/100000057, name: National Institute of General Medical Sciences; DOI: 10.13039/100000738, name: US Department of Veterans Affairs; DOI: 10.13039/100000965, name: American Federation for Aging Research; DOI: 10.13039/100007249, name: University of Minnesota
- Language
- English
- Date published
- 03/15/2024
- Academic Unit
- Pathology
- Record Identifier
- 9984573827802771
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