Journal article
Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus
Lab animal, Vol.38(11), pp.364-368
11/01/2009
DOI: 10.1038/laban1109-364
PMID: 19847180
Abstract
Yellow KK mice carrying the 'yellow obese' gene Ay are a well established polygenic model for human non-insulin dependent diabetes mellitus. These animals develop marked adiposity and decreased glucose tolerance relative to their control littermates, KK mice. The authors monitored glucose tolerance in KK-A(y) mice over time and observed a significant (P <= 0.05) age-dependent improvement (13.3% by 175 d of age and 36.4% by 212 d of age, relative to 85 d of age). During the same time period, body weight and food and water consumption were relatively constant. The authors also measured plasma levels of endocrine hormones that are important in diabetes. Levels of insulin were approximately 8 times higher and levels of amylin 3 times higher in 220-d-old KK-A(y) mice than in 180-d-old mice, whereas levels of glucagon-like peptide 1, glucagon and leptin remained relatively constant. These findings suggest that KK-A(y) mice undergo an age-dependent improvement of glucose tolerance when maintained on a normal diet for 25 weeks or longer, due in part to increases in plasma levels of insulin and amylin.
Details
- Title: Subtitle
- Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus
- Creators
- Goutam Chakraborty - Montclair State UniversitySherin Thumpayil - Montclair State UniversityDavid-Erick Lafontant - Kean UniversityWolde Woubneh - Kean UniversityJeffrey H. Toney - Kean University
- Resource Type
- Journal article
- Publication Details
- Lab animal, Vol.38(11), pp.364-368
- Publisher
- Springer Nature
- DOI
- 10.1038/laban1109-364
- PMID
- 19847180
- ISSN
- 0093-7355
- eISSN
- 1548-4475
- Number of pages
- 5
- Grant note
- Ronald E. McNair Post-Baccalaureate Achievement Program Research Corporation Cottrell College Science Award; Research Corporation For Science Advancement (RCSA) Margaret and Herman Sokol endowment
- Language
- English
- Date published
- 11/01/2009
- Academic Unit
- Biostatistics
- Record Identifier
- 9984771642002771
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