Journal article
Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin
Scientific reports, Vol.5(1), pp.10472-10472
06/02/2015
DOI: 10.1038/srep10472
PMCID: PMC4451800
PMID: 26035055
Abstract
In the skin, aging is associated with overall epidermal thinning, decreased barrier function, and gradual deterioration of the epidermal immune response. However, the presence and role of cytokines, chemokines, and biologic analytes (CCBAs) in immunosenescence are not known. Here we identified age-related changes in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a means to utilize CCBAs as benchmarks for aging skin health. Transepidermal water loss and a(*) (skin redness) decreased in an age-dependent manner, and were significantly lower (p < 0.05) in Groups 2 (56.6 ± 4.6 years) and 3 (72.9 ± 3.0 years) vs. Group 1 (24.3 ± 2.8 years). In skin wash fluid, 48 CCBAs were detected; seven were significantly lower (p < 0.05) in Groups 2 and 3: EGF, FGF-2, IFNα2, IL-1RA, HSA, keratin-6, and involucrin; cortisol was significantly higher (p < 0.05) in Groups 2 and 3. Our results correspond with the pro-inflammatory shift that occurs with immunosenescence and also provides basis for understanding the inflammatory changes in normal aging skin.
Details
- Title: Subtitle
- Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin
- Creators
- Patrick M Kinn - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USAGrant O Holdren - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USABrittney A Westermeyer - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USAMousa Abuissa - Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USACarol L Fischer - Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USAJanet A Fairley - Department of Dermatology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USAKim A Brogden - 1] Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USANicole K Brogden - 1] Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA Department of Dermatology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.5(1), pp.10472-10472
- DOI
- 10.1038/srep10472
- PMID
- 26035055
- PMCID
- PMC4451800
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- England
- Grant note
- R90 DE024296 / NIDCR NIH HHS R01 DE014390 / NIDCR NIH HHS T90 DE023520 / NIDCR NIH HHS
- Language
- English
- Date published
- 06/02/2015
- Academic Unit
- Dermatology; Pharmaceutical Sciences and Experimental Therapeutics; Pharmacy Practice and Science; Periodontics
- Record Identifier
- 9984025449102771
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