Age of retinal hemorrhages by iron detection: an animal model

M G F Gilliland; Robert Folberg; Sohan Singh Hayreh

doi:10.1097/01.paf.0000154113.38906.12

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Age of retinal hemorrhages by iron detection: an animal model

Journal article

Peer reviewed

Age of retinal hemorrhages by iron detection: an animal model

M G F Gilliland, Robert Folberg and Sohan Singh Hayreh

The American journal of forensic medicine and pathology, Vol.26(1), pp.1-4

03/2005

DOI: 10.1097/01.paf.0000154113.38906.12

PMID: 15725769

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Abstract

Intraretinal hemorrhages have been found in some abusively injured infants and children. Intraretinal hemosiderin has been proposed as an indication of previous injury. The limits of the accuracy of the proposal have not been established. Experimental central retinal vein occlusion (CRVO) was produced in 20 eyes of adult rhesus monkeys as part of ongoing research by one of the authors (SSH). The animal experiments were conducted in accordance with a research protocol approved by the Animal Care Committee, University of Iowa. CRVO produced diffuse intraretinal hemorrhages. Clinical ocular examinations assessed the onset and time course of retinal hemorrhages. Enucleation specimens were used to assess hemosiderin in the retinas. Hemosiderin was detected within 2 days of induction of retinal hemorrhages. It was detected in only 4 of 11 eyes (36%) studied more than 1 week following induction of hemorrhages. In 2 eyes, hemosiderin was found 9 and 16.8 months after development of hemorrhages. Hemosiderin can represent organization of current hemorrhage rather than evidence of prior hemorrhage. This study does not allow specifying the duration of hemorrhages with greater precision than "more than 2 days prior to death," and that, only if there is no survival interval. Failure to detect hemosiderin does not exclude prior retinal hemorrhages.

Animals

Child Abuse - diagnosis

Child, Preschool

Forensic Medicine

Hemosiderin - analysis

Humans

Macaca mulatta

Models, Animal

Predictive Value of Tests

Retinal Hemorrhage - pathology

Retinal Vein Occlusion - pathology

Time Factors

Details

Title: Subtitle: Age of retinal hemorrhages by iron detection: an animal model
Creators: M G F Gilliland - East Carolina University
Robert Folberg
Sohan Singh Hayreh
Resource Type: Journal article
Publication Details: The American journal of forensic medicine and pathology, Vol.26(1), pp.1-4
DOI: 10.1097/01.paf.0000154113.38906.12
PMID: 15725769
ISSN: 0195-7910
eISSN: 1533-404X
Grant note: EY-01576 / NEI NIH HHS
Language: English
Date published: 03/2005
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984182760402771

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12 Times Cited - Web of Science