Journal article
Age-related changes in regional cerebral blood flow among young to mid-life adults
Neuroreport, Vol.10(12), pp.2493-2496
08/20/1999
DOI: 10.1097/00001756-199908200-00011
PMID: 10574358
Abstract
Using PET with [(15)O]H2O, we examined age in relation to regional cerebral blood flow (rCBF) among young to mid-life adults. Previous work has largely contrasted rCBF between young and elderly age groups dichotomously. This study maps the continuum of normal age-related changes in rCBF from early to mid-adulthood. We obtained images from 37 healthy volunteers between 19 and 50 years of age during an eyes-closed resting baseline condition. There was a negative correlation between age and rCBF in mesial frontal cortex, involving the anterior cingulate region (r = 0.63, p<0.001). These findings reflect differences in the distribution of rCBF evident in early to mid-adulthood that may be associated with subsequent changes in memory and executive functioning in later life.
Details
- Title: Subtitle
- Age-related changes in regional cerebral blood flow among young to mid-life adults
- Creators
- S K Schultz - Mental Health Clinical Research Center, University of Iowa, Iowa City 52242, USAD S O'LearyL L Boles PontoG L WatkinsR D HichwaN C Andreasen
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.10(12), pp.2493-2496
- Publisher
- England
- DOI
- 10.1097/00001756-199908200-00011
- PMID
- 10574358
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Grant note
- MH31593 / NIMH NIH HHS MH40856 / NIMH NIH HHS MHCRC43271 / NIMH NIH HHS
- Language
- English
- Date published
- 08/20/1999
- Academic Unit
- Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984004186202771
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