Age-related changes in release of endothelium-derived relaxing factor from the carotid artery

R Paternò; F M Faraci; D D Heistad

doi:10.1161/01.STR.25.12.2457

Back

Age-related changes in release of endothelium-derived relaxing factor from the carotid artery

Journal article

Open access

Peer reviewed

Age-related changes in release of endothelium-derived relaxing factor from the carotid artery

R Paternò, F M Faraci and D D Heistad

Stroke (1970), Vol.25(12), pp.2457-2460

12/1994

DOI: 10.1161/01.STR.25.12.2457

PMID: 7974590

Files and links (1)

url

https://doi.org/10.1161/01.STR.25.12.2457View

Published (Version of record) Open Access

Abstract

The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats), and 30 to 32 months old (very old rats). We used a bioassay technique to measure release of EDRF from the carotid artery (donor vessel) and, in the same experiment, measured the diameter of pressurized donor arteries. Responses of the donor arteries and the detector vessels (aortas) to sodium nitroprusside were not altered in old (24 to 26 months) and very old (30 to 32 months) rats compared with responses in the young rats. Dilator responses in the carotid artery to acetylcholine tended to be lower in the old rats and were significantly lower in very old rats compared with the young rats. Relaxation of the detector vessel during administration of acetycholine to the donor artery was not significantly different in young, old, and very old rats. Endothelium-dependent dilatation in carotid arteries of old rats is impaired, but release of EDRF and responsiveness of vascular muscle to nitroprusside are normal. Thus, impairment of endothelium-dependent relaxation in the carotid artery during aging is not due to impaired release of EDRF.

Blood Pressure

Muscle, Smooth, Vascular - metabolism

Rats, Wistar

Acetylcholine - pharmacology

Carotid Artery, Common - metabolism

Vasoconstriction

Aorta, Thoracic - metabolism

Rats

Endothelium, Vascular - drug effects

Nitroprusside - pharmacology

Animals

Phenylephrine - pharmacology

Image Processing, Computer-Assisted

Endothelium, Vascular - metabolism

Carotid Artery, Common - drug effects

Biological Assay

Aorta, Thoracic - drug effects

Vasodilation - drug effects

Nitric Oxide - metabolism

Aging - metabolism

Muscle, Smooth, Vascular - drug effects

Details

Title: Subtitle: Age-related changes in release of endothelium-derived relaxing factor from the carotid artery
Creators: R Paternò - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242-1081
F M Faraci
D D Heistad
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.25(12), pp.2457-2460
Publisher: United States
DOI: 10.1161/01.STR.25.12.2457
PMID: 7974590
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 12/1994
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040550902771

Metrics

24 Record Views

20 Times Cited - Web of Science