Journal article
Age-related differences in water and sodium handling after commercial hydration beverage ingestion
Journal of applied physiology (1985), Vol.126(4), pp.1042-1048
02/14/2019
DOI: 10.1152/japplphysiol.01094.2018
PMCID: PMC6485687
PMID: 30763158
Abstract
Aging is associated with altered water, electrolyte, and glucose handling. Alternative beverages to those containing carbohydrate (CHO) should be considered for older adults. We hypothesized that reduced sodium (CNa
+
) and/or water (CH
2
O) clearance would underlie greater beverage retention in older compared with young adults, secondary to reduced glomerular filtration rate (GFR). We further hypothesized that amino acid (AA)- and CHO-based beverages would promote retention better than water. Over five visits, 12 young (23 ± 3 yr; 7 men, 5 women) and 12 older (67 ± 6 yr; 5 men, 7 women) subjects consumed 1 liter of distilled water or beverages with 6% CHO, 0.46 g/l Na
+
[Gatorade (GAT)]; 2.5% CHO, 0.74 g/l Na
+
[Pedialyte (PED)]; 5 AA, 1.04 g/l Na
+
[enterade (ENT)-5]; or 8 AA, 1.38 g/l Na
+
(ENT-8) over 30 min. Blood and urine were collected every hour for 4 h after ingestion; retention, CH
2
O, and CNa
+
were calculated at 2 and 4 h. Additional calculations adjusted CH
2
O and CNa
+
for estimated GFR (eGFR). Water yielded the lowest retention in both groups (
P
≤ 0.02). Retention was higher in older vs. young adults except for ENT-8 at 4 h (
P
= 0.73). CH
2
O was higher for older vs. young adults for GAT at 2 h (
P
< 0.01) and GAT and PED at 4 h (
P
< 0.01) after ingestion but was otherwise similar between groups. CNa
+
was lower in older vs. young adults except for ENT-8 (
P
≥ 0.19). Adjusting for eGFR resulted in higher CH
2
O for all beverages in older vs. young adults (
P
< 0.05) but did not influence CNa
+
. Older adults may better retain beverages with less Na
+
than young adults because of reduced CNa
+
. AA- and CHO-based electrolyte-rich beverages may similarly promote beverage retention.
NEW & NOTEWORTHY
Commercially available amino acid (AA)-containing beverages may provide an alternative to traditional carbohydrate (CHO)-containing beverages, particularly for older adults with attenuated water, electrolyte, and glucose handling. We compared beverage retention and free water and sodium clearance between young and older adults after ingestion of water, two CHO-based beverages, and two AA-based beverages. Our data suggest that older adults better retain beverages with less sodium compared with young adults and that AA-based and CHO-based electrolyte-containing beverages similarly promote retention.
Details
- Title: Subtitle
- Age-related differences in water and sodium handling after commercial hydration beverage ingestion
- Creators
- S. Tony Wolf - Pennsylvania State UniversityAnna E Stanhewicz - Pennsylvania State UniversityMegan M Clarke - Pennsylvania State UniversitySamuel N Cheuvront - United States Department of the ArmyRobert W Kenefick - United States Department of the ArmyW. Larry Kenney - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.126(4), pp.1042-1048
- Publisher
- American Physiological Society
- DOI
- 10.1152/japplphysiol.01094.2018
- PMID
- 30763158
- PMCID
- PMC6485687
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Grant note
- 5T32AG049676-03 / ;
- Alternative title
- AGE AND FLUID HANDLING
- Language
- English
- Date published
- 02/14/2019
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259646702771
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