Journal article
Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study
Journal of cystic fibrosis, Vol.17(6), pp.747-759
11/2018
DOI: 10.1016/j.jcf.2018.06.009
PMCID: PMC6589399
PMID: 30005828
Abstract
The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls.
Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF.
Children ages 6-9 with CF had significantly lower caries than controls (Holm’s P<0.05). There was no difference for ages 10-20 by CF status (Holm’s P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF.
Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.
Details
- Title: Subtitle
- Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study
- Creators
- Donald L. Chi - University of WashingtonMargaret Rosenfeld - Seattle Children's HospitalLloyd Mancl - University of WashingtonWhasun O. Chung - University of WashingtonRichard B. Presland - University of WashingtonElise Sarvas - University of MinnesotaMarilynn Rothen - University of WashingtonAlaa Alkhateeb - University of WashingtonSharon McNamara - Seattle Children's HospitalAlan Genatossio - Seattle Children's HospitalIsabel Virella-Lowell - University of Alabama at BirminghamCarlos Milla - Stanford UniversityJoAnna Scott - University of Missouri–Kansas City
- Resource Type
- Journal article
- Publication Details
- Journal of cystic fibrosis, Vol.17(6), pp.747-759
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jcf.2018.06.009
- PMID
- 30005828
- PMCID
- PMC6589399
- ISSN
- 1569-1993
- eISSN
- 1873-5010
- Grant note
- name: Sunstar Americas Pediatric Prevention Award; DOI: 10.13039/100007812, name: University of Washington; name: Cystic Fibrosis Foundation Research Development Program; name: the U.S. National Institute of Dental and Craniofacial Research, award: K08DE020856, T90DE021984; name: U.S. National Institute of Health National Center for Advancing Translational Sciences; name: Clinical and Translational Science Award, award: UL1TR002319; DOI: 10.13039/501100002383, name: King Saud University; name: William T. Grant Foundation Scholars Program; DOI: 10.13039/100005541, name: Center for Advanced Study in the Behavioral Sciences; DOI: 10.13039/100005492, name: Stanford University
- Language
- English
- Date published
- 11/2018
- Academic Unit
- Public Policy Center (Archive)
- Record Identifier
- 9984283711802771
Metrics
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