Journal article
Age-related neuronal vulnerability to brain ischemia: A potential target of gene therapy
Journal of the American Aging Association, Vol.24(1), pp.31-35
01/01/2001
DOI: 10.1007/s11357-001-0004-6
PMCID: PMC3455646
PMID: 23604873
Abstract
Brain infarction is one of the most important age-associated diseases. We have developed aged animal models for brain ischemia, and found the age-related neuronal vulnerability to brain ischemia. Investigation of that mechanism would lead to the effective treatment of brain infarction in the elder population. Recent advancement of gene transfer technique has provided strong tools for the neuronal and vascular biology. We described our recent approaches of gene transfer to blood vessels, including cerebral circulation, using adenoviral vectors. Cerebral blood vessels, atherosclerotic endothelium, and ischemic brain tissue are good targets of gene transfer. Development of these techniques would offer new therapeutic strategies for the age-related neuronal vulnerability and other age-associated diseases.
Details
- Title: Subtitle
- Age-related neuronal vulnerability to brain ischemia: A potential target of gene therapy
- Creators
- Hiroaki Ooboshi - Kyushu UniversitySetsuro Ibayashi - Kyushu UniversityHiroshi Yao - Kyushu UniversityJunichi Takada - Kyushu UniversityDonald D. Heistad - University of IowaMasatoshi Fujishima - Kyushu University
- Resource Type
- Journal article
- Publication Details
- Journal of the American Aging Association, Vol.24(1), pp.31-35
- DOI
- 10.1007/s11357-001-0004-6
- PMID
- 23604873
- PMCID
- PMC3455646
- NLM abbreviation
- Age (Dordr)
- ISSN
- 2152-4041
- eISSN
- 1574-4647
- Publisher
- Kluwer Academic Publishers
- Language
- English
- Date published
- 01/01/2001
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984303858402771
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