Journal article
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity
The Journal of clinical investigation, Vol.130(12), pp.6204-6213
12/01/2020
DOI: 10.1172/JCI144115
PMCID: PMC7685716
PMID: 33085654
Abstract
Human coronaviruses (hCoVs) cause severe respiratory illness in the elderly. Age-related impairments in innate immunity and suboptimal virus-specific T cell and antibody responses are believed to cause severe disease upon respiratory virus infections. This phenomenon has recently received increased attention, as elderly patients are at substantially elevated risk for severe COVID-19 disease and experience increased rates of mortality following SARS-CoV-2 infection compared with younger populations. However, the basis for age-related fatal pneumonia following pathogenic hCoVs is not well understood. In this Review, we provide an overview of our current understanding of hCoV-induced fatal pneumonia in the elderly. We describe host immune response to hCoV infections derived from studies of young and aged animal models and discuss the potential role of age-associated increases in sterile inflammation (inflammaging) and virus-induced dysregulated inflammation in causing age-related severe disease. We also highlight the existing gaps in our knowledge about virus replication and host immune responses to hCoV infection in young and aged individuals.
Details
- Title: Subtitle
- Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity
- Creators
- Rudragouda Channappanavar - Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USAStanley Perlman - Stead Family Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.130(12), pp.6204-6213
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI144115
- PMID
- 33085654
- PMCID
- PMC7685716
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Grant note
- P01 AI060699 / NIAID NIH HHS\nR21 AG060222 / NIA NIH HHS\nR01 AI129269 / NIAID NIH HHS
- Language
- English
- Date published
- 12/01/2020
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984070281102771
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