Journal article
Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers
International journal of cancer, Vol.108(5), pp.766-772
2004
DOI: 10.1002/ijc.11633
PMID: 14696105
Abstract
There are few well-established patient risk factors associated with human papillomavirus (HPV) infection in cancers of the oral cavity and oropharynx. The purpose of this study was to determine if there were significant different risk factors and tumor characteristics between HPV-positive and HPV-negative cancer cases. HPV was evaluated in cancer tissue and exfoliated oral cells of 193 oral cavity/oropharynx cancer patients using PCR and direct DNA sequencing. A patient questionnaire collected information about risk factors, sexual practices and medical history. The prevalence of HPV high-risk (HR) types was 20% in cancer cases. Three types were identified: HPV-16 (87%), HPV-18 (3%) and HPV-33 (11%). Risk factors for HPV-HR included younger age (≤ 55 years vs. > 55 years; adjusted OR = 3.4; 95% CI = 1.6–7.3) and younger-age cases who had more lifetime sex partners (adjusted OR = 3.8; 95% CI = 1.4–10.1), practiced oral-genital sex (adjusted OR = 4.3; 95% CI = 1.8–10.4) or oral-anal sex (adjusted OR = 19.5; 95% CI = 3.4–113). Compared to HPV-negative cancers, HPV-HR cancers were more likely to have a positive HPV-HR exfoliated oral cytology test (adjusted OR = 7.8; 95% CI = 3.4–18.4), later stage (adjusted OR = 3.0), nodal involvement (adjusted OR = 4.1) and advanced grade (adjusted OR = 3.0). This study shows new evidence that the prevalence of oncogenic mucosal HPV is higher in younger-age oral cavity/oropharynx cancer cases whose sexual practices are typically associated with sexual transmission of the virus. HPV detection also appears to be an indicator of advanced disease characteristics that may require different clinical treatment for this subset of patients. An exfoliated oral cytology test for HPV was a significant predictor of HR types in the cancers, suggesting that an oral rinse may provide an early biomarker of infected tumors.
Details
- Title: Subtitle
- Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers
- Creators
- Elaine M SMITH - Department of Epidemiology, College of Public Health, University of Iowa., Iowa City, IA, United StatesJustine M RITCHIE - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, United StatesKurt F SUMMERSGILL - Department of Oral Medicine and Pathology, School of Dental Medicine, University of Pittisburgh, Pittsburgh, PA, United StatesJens P KLUSSMANN - Department of Otolaryngology, University of Cologne, Cologne, GermanyJohn H LEE - Department of Ololaryngology, College of Medicine, University of Iowa, Iowa City, IA, United StatesDonghong WANG - Department of Epidemiology, College of Public Health, University of Iowa., Iowa City, IA, United StatesThomas H HAUGEN - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA, United StatesLubomir P TUREK - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.108(5), pp.766-772
- Publisher
- Wiley-Liss; New York, NY
- DOI
- 10.1002/ijc.11633
- PMID
- 14696105
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Language
- English
- Date published
- 2004
- Academic Unit
- Epidemiology; Pathology; Otolaryngology
- Record Identifier
- 9984047771102771
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