Journal article
Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection
Journal of virology, Vol.87(23), pp.12694-12700
12/2013
DOI: 10.1128/JVI.02282-12
PMCID: PMC3838124
PMID: 24049171
Abstract
Respiratory virus infections in the elderly result in increased rates of hospitalization and death. Respiratory syncytial virus (RSV) is a leading cause of severe virus-induced respiratory disease in individuals over the age of 65. CD8 T cells play a critical role in mediating RSV clearance. While it is clear that T cell immunity declines with age, it is not clear to what extent the CD8 T cell response to RSV is altered. Using aged BALB/c mice, we demonstrated that RSV-specific CD8 T cell responses were significantly reduced in the lungs of aged mice at the peak of the T cell response and that this decrease correlated with delayed viral clearance. Despite a decrease in the overall numbers of RSV-specific CD8 T cells during acute infection, their capacity to produce effector cytokines was not impaired. Following viral clearance, the RSV-specific memory CD8 T cells were similar in total number and phenotype in young and aged mice. Furthermore, following infection with a heterologous pathogen expressing an RSV epitope, RSV-specific memory CD8 T cells exhibited similar activation and ability to provide early control of the infection in young and aged mice. These data demonstrate a decrease in the capacity of aged mice to induce a high-magnitude acute CD8 T cell response, leading to prolonged viral replication, which may contribute to the increased disease severity of RSV infection observed for aged individuals.
Details
- Title: Subtitle
- Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection
- Creators
- Ross B Fulton - Department of MicrobiologyKayla A Weiss - Interdisciplinary Graduate Program in ImmunologyLecia L Pewe - Department of MicrobiologyJohn T Harty - Department of MicrobiologySteven M Varga - Department of Microbiology
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.87(23), pp.12694-12700
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- DOI
- 10.1128/JVI.02282-12
- PMID
- 24049171
- PMCID
- PMC3838124
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English
- Date published
- 12/2013
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984046802702771
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