Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment

Robert W Eppsteiner; Jonathan W Fowlkes; Carryn M Anderson; Robert A Robinson; Nitin A Pagedar

doi:10.1177/0003489417702655

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Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment

Journal article

Peer reviewed

Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment

Robert W Eppsteiner, Jonathan W Fowlkes, Carryn M Anderson, Robert A Robinson and Nitin A Pagedar

Annals of otology, rhinology & laryngology, Vol.126(7), pp.525-529

07/2017

DOI: 10.1177/0003489417702655

PMID: 28474964

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Abstract

Few studies have examined whether the use of adjuvant treatment impacts survival for early stage high-grade salivary tumors. A retrospective review of the SEER database between 1973 and 2012 was performed. Patients with high-grade major salivary gland tumors including salivary duct carcinoma, carcinoma ex-pleomorphic adenoma, high-grade mucoepidermoid carcinoma, or adenocarcinoma, NOS were identified. Only stage I-II tumors were included. The impact of radiation status on observed and relative survival was examined. Five hundred seventy-four patients with high-grade, early stage salivary tumors met inclusion criteria. Sixty-seven percent of patients received radiation therapy. There was no difference in observed or relative survival based on having received radiation. Adjuvant radiation is indicated for advanced stage tumors or early stage tumors with adverse features. For early stage tumors without adverse features, there was no survival benefit from radiation therapy. Adjuvant radiation should be decided on a case-by-case basis for these patients.

Salivary Gland Neoplasms - mortality

Adenocarcinoma - pathology

Adenoma, Pleomorphic - radiotherapy

Humans

Middle Aged

Male

Young Adult

Carcinoma, Mucoepidermoid - radiotherapy

Neoplasm Grading

Adenoma, Pleomorphic - surgery

Aged, 80 and over

Adult

Female

Retrospective Studies

Radiotherapy, Adjuvant

Child

Adenocarcinoma - radiotherapy

Treatment Outcome

Carcinoma, Mucoepidermoid - surgery

Adenoma, Pleomorphic - mortality

Carcinoma, Mucoepidermoid - pathology

Adenoma, Pleomorphic - pathology

Adolescent

Survival Analysis

Salivary Gland Neoplasms - radiotherapy

Salivary Ducts - pathology

Salivary Ducts - surgery

Aged

Carcinoma, Mucoepidermoid - mortality

Neoplasm Staging

Salivary Gland Neoplasms - pathology

Adenocarcinoma - mortality

Adenocarcinoma - surgery

Salivary Gland Neoplasms - surgery

Details

Title: Subtitle: Aggressive Salivary Malignancies at Early Stage: Outcomes and Implications for Treatment
Creators: Robert W Eppsteiner - 1 Departments of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Jonathan W Fowlkes - 1 Departments of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Carryn M Anderson - 2 Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Robert A Robinson - 3 Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Nitin A Pagedar - 1 Departments of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, Vol.126(7), pp.525-529
Publisher: United States
DOI: 10.1177/0003489417702655
PMID: 28474964
ISSN: 0003-4894
eISSN: 1943-572X
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 07/2017
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Radiation Oncology; Otolaryngology
Record Identifier: 9984047898602771

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