Journal article
Aging and plasma triglyceride metabolism
Journal of lipid research, Vol.61(8), pp.1161-1167
08/01/2020
DOI: 10.1194/jlr.R120000922
PMCID: PMC7397742
PMID: 32586846
Abstract
The risk for metabolic disease, including metabolic syndrome, insulin resistance, and diabetes, increases with age. Altered plasma TG metabolism and changes in fatty acid partitioning are also major contributors to metabolic disease. Plasma TG metabolism itself is altered by age in humans and rodents. As discussed in this review, the age-induced changes in human TG metabolism include increased plasma TG levels, reduced postprandial plasma TG clearance rates, reduced postheparin LPL activity, decreased adipose tissue lipolysis, and elevated ectopic fat deposition, all of which could potentially contribute to age-associated metabolic diseases. Similar observations have been made in aged rats. We highlight the limitations of currently available data and propose that mechanistic studies are needed to understand the extent to which age-induced alterations in TG metabolism contribute to metabolic disease. Such mechanistic insights could aid in therapeutic strategies for preventing or managing metabolic disease in older individuals.
Details
- Title: Subtitle
- Aging and plasma triglyceride metabolism
- Creators
- Kathryn M. Spitler - University of IowaBrandon S. J. Davies - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of lipid research, Vol.61(8), pp.1161-1167
- DOI
- 10.1194/jlr.R120000922
- PMID
- 32586846
- PMCID
- PMC7397742
- NLM abbreviation
- J Lipid Res
- ISSN
- 0022-2275
- eISSN
- 1539-7262
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R01 HL130146 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Health, Sport, and Human Physiology
- Record Identifier
- 9984293086102771
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