Aging brain from a network science perspective: something to be positive about?

Michelle W Voss; Chelsea N Wong; Pauline L Baniqued; Jonathan H Burdette; Kirk I Erickson; Ruchika Shaurya Prakash; Edward McAuley; Paul J Laurienti; Arthur F Kramer

doi:10.1371/journal.pone.0078345

Back

Aging brain from a network science perspective: something to be positive about?

Journal article

Open access

Peer reviewed

Aging brain from a network science perspective: something to be positive about?

Michelle W Voss, Chelsea N Wong, Pauline L Baniqued, Jonathan H Burdette, Kirk I Erickson, Ruchika Shaurya Prakash, Edward McAuley, Paul J Laurienti and Arthur F Kramer

PloS one, Vol.8(11), pp.e78345-e78345

2013

DOI: 10.1371/journal.pone.0078345

PMCID: PMC3819386

PMID: 24223147

Files and links (1)

url

https://doi.org/10.1371/journal.pone.0078345View

Published (Version of record) Open Access

Abstract

To better understand age differences in brain function and behavior, the current study applied network science to model functional interactions between brain regions. We observed a shift in network topology whereby for older adults subcortical and cerebellar structures overlapping with the Salience network had more connectivity to the rest of the brain, coupled with fragmentation of large-scale cortical networks such as the Default and Fronto-Parietal networks. Additionally, greater integration of the dorsal medial thalamus and red nucleus in the Salience network was associated with greater satisfaction with life for older adults, which is consistent with theoretical predictions of age-related increases in emotion regulation that are thought to help maintain well-being and life satisfaction in late adulthood. In regard to cognitive abilities, greater ventral medial prefrontal cortex coherence with its topological neighbors in the Default Network was associated with faster processing speed. Results suggest that large-scale organizing properties of the brain differ with normal aging, and this perspective may offer novel insight into understanding age-related differences in cognitive function and well-being.

Humans

Middle Aged

Male

Cognition

Cerebellum - physiology

Nerve Net - physiology

Neural Pathways

Personal Satisfaction

Aging - physiology

Thalamus - physiology

Brain Mapping

Adult

Female

Parietal Lobe - physiology

Aged

Quality of Life - psychology

Behavior

Prefrontal Cortex - physiology

Task Performance and Analysis

Details

Title: Subtitle: Aging brain from a network science perspective: something to be positive about?
Creators: Michelle W Voss - Department of Psychology, University of Iowa, Iowa City, Iowa, United States of America
Chelsea N Wong
Pauline L Baniqued
Jonathan H Burdette
Kirk I Erickson
Ruchika Shaurya Prakash
Edward McAuley
Paul J Laurienti
Arthur F Kramer
Resource Type: Journal article
Publication Details: PloS one, Vol.8(11), pp.e78345-e78345
DOI: 10.1371/journal.pone.0078345
PMID: 24223147
PMCID: PMC3819386
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: R37 AG025667 / NIA NIH HHS UL1 TR000005 / NCATS NIH HHS R01 AG25032 / NIA NIH HHS
Language: English
Date published: 2013
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002471402771

Metrics

36 Record Views

11 Times Cited - Web of Science