Aging impairs hippocampus-dependent long-term memory for object location in mice

Mathieu E Wimmer; Pepe J Hernandez; Jennifer Blackwell; Ted Abel

doi:10.1016/j.neurobiolaging.2011.07.007

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Aging impairs hippocampus-dependent long-term memory for object location in mice

Journal article

Peer reviewed

Aging impairs hippocampus-dependent long-term memory for object location in mice

Mathieu E Wimmer, Pepe J Hernandez, Jennifer Blackwell and Ted Abel

Neurobiology of aging, Vol.33(9), pp.2220-2224

09/2012

DOI: 10.1016/j.neurobiolaging.2011.07.007

PMCID: PMC3227775

PMID: 21872364

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https://www.ncbi.nlm.nih.gov/pmc/articles/3227775View

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Abstract

The decline in cognitive function that accompanies normal aging has a negative impact on the quality of life of the elderly and their families. Studies in humans and rodents show that spatial navigation and other hippocampus-dependent functions are particularly vulnerable to the deleterious effects of aging. However, reduced motor activity and alterations in the stress response that accompany normal aging can hinder the ability to study certain cognitive behaviors in aged animals. In an attempt to circumvent these potential confounds, we used a hippocampus-dependent object-place recognition task to show that long-term spatial memory is impaired in aged mice. Aged animals performed similarly to young adult mice on an object recognition task that does not rely on hippocampal function.

Aging

Mice

Object recognition

Hippocampus

Spatial memory

Details

Title: Subtitle: Aging impairs hippocampus-dependent long-term memory for object location in mice
Creators: Mathieu E Wimmer - Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA, USA
Pepe J Hernandez - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Jennifer Blackwell - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Ted Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Resource Type: Journal article
Publication Details: Neurobiology of aging, Vol.33(9), pp.2220-2224
DOI: 10.1016/j.neurobiolaging.2011.07.007
PMID: 21872364
PMCID: PMC3227775
NLM abbreviation: Neurobiol Aging
ISSN: 0197-4580
eISSN: 1558-1497
Publisher: Elsevier Inc
Grant note: name: NIA, award: 5P01AG017628-09; DOI: 10.13039/100000050, name: NHLBI, award: T32HL007953-11A1; DOI: 10.13039/100000065, name: NINDS, award: T32NS00743-13; name: NSF minority postdoctoral fellowship, award: 0706858
Language: English
Date published: 09/2012
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984065838602771

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