Journal article
Aging in mice reduces the ability to sustain sleep/wake states
PloS one, Vol.8(12), pp.e81880-e81880
2013
DOI: 10.1371/journal.pone.0081880
PMCID: PMC3864844
PMID: 24358130
Abstract
One of the most significant problems facing older individuals is difficulty staying asleep at night and awake during the day. Understanding the mechanisms by which the regulation of sleep/wake goes awry with age is a critical step in identifying novel therapeutic strategies to improve quality of life for the elderly. We measured wake, non-rapid eye movement (NREM) and rapid-eye movement (REM) sleep in young (2-4 months-old) and aged (22-24 months-old) C57BL6/NIA mice. We used both conventional measures (i.e., bout number and bout duration) and an innovative spike-and-slab statistical approach to characterize age-related fragmentation of sleep/wake. The short (spike) and long (slab) components of the spike-and-slab mixture model capture the distribution of bouts for each behavioral state in mice. Using this novel analytical approach, we found that aged animals are less able to sustain long episodes of wakefulness or NREM sleep. Additionally, spectral analysis of EEG recordings revealed that aging slows theta peak frequency, a correlate of arousal. These combined analyses provide a window into the mechanisms underlying the destabilization of long periods of sleep and wake and reduced vigilance that develop with aging.
Details
- Title: Subtitle
- Aging in mice reduces the ability to sustain sleep/wake states
- Creators
- Mathieu E Wimmer - Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America ; Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of AmericaJustin Rising - Statistics Department, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania, United States of AmericaRaymond J Galante - Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of AmericaAbraham Wyner - Statistics Department, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania, United States of AmericaAllan I Pack - Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America ; Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of AmericaTed Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America ; Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.8(12), pp.e81880-e81880
- DOI
- 10.1371/journal.pone.0081880
- PMID
- 24358130
- PMCID
- PMC3864844
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- P01 AG017628 / NIA NIH HHS T32HL007953 / NHLBI NIH HHS 5P01AG017628 / NIA NIH HHS T32 HL007953 / NHLBI NIH HHS
- Language
- English
- Date published
- 2013
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065821702771
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