Journal article
Aging reduces adaptive capacity and stress protein expression in the liver after heat stress
Journal of applied physiology (1985), Vol.89(2), pp.749-759
08/01/2000
DOI: 10.1152/jappl.2000.89.2.749
PMID: 10926662
Abstract
A decline in an organism's ability to cope with stress through acute response protein expression may contribute to stress intolerance with aging. We investigated the influence of aging on stress tolerance and the capacity to synthesize the 70-kDa heat shock protein (HSP70) in young and old rats exposed to an environmental heating protocol. Livers were assessed for injury and HSP70 expression after heat stress by use of immunohistochemical and immunoblotting techniques. The inducible HSP70 response in the cytoplasm and nucleus was markedly reduced with age at several time points over a 48-h recovery period, although senescent rats were able to strongly express HSP70 early in recovery. Older animals had extensive zone-specific liver injury, which corresponded to the diminished HSP70 response observed in these regions, and a significant reduction in thermotolerance compared with their young counterparts. These data highlight the regional nature of stress-induced injury and HSP70 expression in the liver and the impact of aging on these responses. Furthermore, the results suggest a functional link between the age-related decrements in the expression of inducible HSP70 and the pathophysiological responses to heat stress.
Details
- Title: Subtitle
- Aging reduces adaptive capacity and stress protein expression in the liver after heat stress
- Creators
- D. M Hall - Department of Exercise Science, andL Xu - Department of Exercise Science, andV. J Drake - Department of Exercise Science, andL. W Oberley - Radiation Research Laboratory, The University of Iowa, Iowa City, Iowa 52242T. D Oberley - Department of Pathology and Veterans Affairs Hospitals and Clinics, University of Wisconsin, Madison, Wisconsin 53705; andP. L Moseley - Department of Internal Medicine and Laboratory of Environmental Stress and Adaptation, University of New Mexico, Albuquerque, New Mexico 87131K. C Kregel - Department of Exercise Science, and
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.89(2), pp.749-759
- DOI
- 10.1152/jappl.2000.89.2.749
- PMID
- 10926662
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 08/01/2000
- Academic Unit
- Radiation Oncology; Provost Office Administration; Health and Human Physiology
- Record Identifier
- 9984213309802771
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