Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository

Rayna K Matsuno; Mark E Sherman; Kala Visvanathan; Marc T Goodman; Brenda Y Hernandez; Charles F Lynch; Olga B Ioffe; David Horio; Charles Platz; Sean F Altekruse; Ruth M Pfeiffer; William F Anderson

doi:10.1007/s10552-013-0157-5

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Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository

Journal article

Peer reviewed

Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository

Rayna K Matsuno, Mark E Sherman, Kala Visvanathan, Marc T Goodman, Brenda Y Hernandez, Charles F Lynch, Olga B Ioffe, David Horio, Charles Platz, Sean F Altekruse, …

Cancer causes & control, Vol.24(4), pp.749-757

04/2013

DOI: 10.1007/s10552-013-0157-5

PMCID: PMC4000689

PMID: 23378140

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Abstract

Emerging data suggest that ovarian cancers differ by tumor grade. However, the reliability of microscopic grade from paraffin tissue in the general medical community and as reflected in population-based cancer registries is unknown. We examined grade agreement between two gynecologic pathologists and the Surveillance Epidemiology and End Results Residual Tissue Repository (SEER). Grade agreement was assessed with percent observer agreement and kappa coefficients for 664 invasive ovarian carcinomas, using previously defined three-tier and two-tier grading systems. A random subset of ovarian carcinomas was selected to compare intra- and inter-pathologist agreement. Five hundred and eighty-six of SEER's 664 tumors were confirmed invasive. Percent agreement was 49 % with fair kappa coefficient = 0.25 (95 % CI: 0.20-0.30) for the 664 tumors. Agreement improved slightly when restricted to the 586 confirmed invasive cancers; it was better for high grade than low grade tumors, for two-tier than three-tier grading systems, and within (66 %) than between study pathologists (43 %). Grade was not a robust independent predictor of ovarian cancer-specific survival. Grade agreement was fair between SEER and study pathologists irrespective of grading system. Recorded grade in SEER should be used with caution and is probably not a reliable metric for ovarian cancer epidemiology.

United States - epidemiology

Prognosis

Follow-Up Studies

Humans

Middle Aged

Ovarian Neoplasms - pathology

Adenocarcinoma, Clear Cell - etiology

Ovarian Neoplasms - mortality

Adenocarcinoma, Clear Cell - blood

Formaldehyde

Paraffin Embedding

Neoplasm Grading

Adenocarcinoma, Mucinous - blood

Adult

Female

Cystadenocarcinoma, Serous - blood

SEER Program

Cystadenocarcinoma, Serous - etiology

Risk Factors

Adenocarcinoma, Mucinous - etiology

Endometrial Neoplasms - etiology

Survival Rate

Adenocarcinoma, Clear Cell - diagnosis

Endometrial Neoplasms - diagnosis

Ovarian Neoplasms - epidemiology

Adenocarcinoma, Mucinous - diagnosis

Aged

Cystadenocarcinoma, Serous - diagnosis

Neoplasm Staging

Endometrial Neoplasms - blood

Population Surveillance

Details

Title: Subtitle: Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository
Creators: Rayna K Matsuno - DHHS/NIH/National Cancer Institute/Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
Mark E Sherman
Kala Visvanathan
Marc T Goodman
Brenda Y Hernandez
Charles F Lynch
Olga B Ioffe
David Horio
Charles Platz
Sean F Altekruse
Ruth M Pfeiffer
William F Anderson
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.24(4), pp.749-757
DOI: 10.1007/s10552-013-0157-5
PMID: 23378140
PMCID: PMC4000689
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: R01 CA058598 / NCI NIH HHS N01PC35143 / NCI NIH HHS ZIA CP010183-11 / Intramural NIH HHS N01PC35137 / NCI NIH HHS
Language: English
Date published: 04/2013
Academic Unit: Epidemiology; Pathology
Record Identifier: 9983995148502771

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