Journal article
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
The Science of the total environment, Vol.448, pp.48-55
03/15/2013
DOI: 10.1016/j.scitotenv.2012.11.070
PMCID: PMC4327853
PMID: 23273373
Abstract
Information on how ambient air pollution affects susceptible populations is needed to ensure protective air quality standards.
To estimate the effect of community-level ambient particulate matter (PM) and ozone (O3) on respiratory symptoms among primarily African-American and Latino, lower-income asthmatic children living in Detroit, Michigan and to evaluate factors associated with heterogeneity in observed health effects.
A cohort of 298 children with asthma was studied prospectively from 1999 to 2002. For 14days each season over 11 seasons, children completed a respiratory symptom diary. Simultaneously, ambient pollutant concentrations were measured at two community-level monitoring sites. Logistic regression models using generalized estimating equations were fit for each respiratory symptom in single pollutant models, looking for interactions by area or by corticosteroid use, a marker of more severe asthma. Exposures of interest were: daily concentrations of PM<10μm, <2.5μm, and between 10 and 2.5μm in aerodynamic diameter (PM10, PM2.5, and PM10–2.5, respectively), the daily 8-hour maximum concentration of O3 (8HrPeak), and the daily 1-hour maximum concentration of O3 (1HrPeak).
Outdoor PM2.5, PM10, 8HrPeak, and 1HrPeak O3 concentrations were associated with increased odds of respiratory symptoms, particularly among children using corticosteroid medication and among children living in the southwest community of Detroit. Similar patterns of associations were not seen with PM10–2.5.
PM2.5 and O3 at levels near or below annual standard levels are associated with negative health impact in this population of asthmatic children. Variation in effects within the city of Detroit and among the subgroup using steroids emphasizes the importance of spatially refined exposure assessment and the need for further studies to elucidate mechanisms and effective risk reduction interventions.
► Children with asthma may have heterogeneous responses to air pollution. ► We examined relationships between particulate matter, ozone, and asthma symptoms. ► Impacts of air pollution were stronger among children with more severe asthma. ► Effects of air pollution also differed by location within the City of Detroit.
Details
- Title: Subtitle
- Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
- Creators
- Toby C Lewis - Department of Pediatrics, Division of Pulmonology, University of Michigan Medical School, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-5212, United StatesThomas G Robins - Department of Environmental Health Sciences, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesGraciela B Mentz - Department of Health Behavior and Health Education, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesXiaohui Zhang - Department of Environmental Health Sciences, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesBhramar Mukherjee - Department of Biostatistics, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesXihong Lin - Department of Biostatistics, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesGerald J Keeler - Department of Environmental Health Sciences, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesJ. Timothy Dvonch - Department of Environmental Health Sciences, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesFuyuen Y Yip - Department of Environmental Health Sciences, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesMarie S O'Neill - Department of Environmental Health Sciences, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesEdith A Parker - Department of Health Behavior and Health Education, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesBarbara A Israel - Department of Health Behavior and Health Education, University of Michigan School of Public Health, 1515 Washington Heights, Ann Arbor, MI 48109-2029, United StatesPaul T Max - Detroit Department of Health and Wellness Promotion, Environmental Health and Safety, 1151, Taylor Bldg. 4, Detroit, MI 48202, United StatesAngela Reyes - Detroit Hispanic Development Corporation, 1211 Trumbull Street, Detroit, MI 48216-1940, United States
- Resource Type
- Journal article
- Publication Details
- The Science of the total environment, Vol.448, pp.48-55
- DOI
- 10.1016/j.scitotenv.2012.11.070
- PMID
- 23273373
- PMCID
- PMC4327853
- NLM abbreviation
- Sci Total Environ
- ISSN
- 0048-9697
- eISSN
- 1879-1026
- Publisher
- Elsevier B.V
- Grant note
- R826710 / United States Environmental Protection Agency K23–ES013242; P01-ES09589; R01-ES010688; R01-ES016932 / National Institute of Environmental Health Sciences Robert Wood Johnson Health & Society Scholars Program
- Language
- English
- Date published
- 03/15/2013
- Academic Unit
- Public Health Administration; Injury Prevention Research Center; Public Policy Center (Archive); Community and Behavioral Health
- Record Identifier
- 9984064182502771
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