Journal article
Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study
The European respiratory journal, Vol.50(6), pp.1700559-1700559
12/2017
DOI: 10.1183/13993003.00559-2017
PMCID: PMC5726423
PMID: 29217611
Abstract
We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT).We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM
), nitrogen oxides (NO
), nitrogen dioxide (NO
) and ozone (O
)) at each home. A total of 5495 participants underwent serial assessment of HAAs by cardiac CT; 2671 participants were assessed for ILAs using full lung CT at the 10-year follow-up. We used multivariable logistic regression and linear mixed models adjusted for age, sex, ethnicity, education, tobacco use, scanner technology and study site.The odds of ILAs increased 1.77-fold per 40 ppb increment in NO
(95% CI 1.06 to 2.95, p = 0.03). There was an overall trend towards an association between higher exposure to NO
and greater progression of HAAs (0.45% annual increase in HAAs per 40 ppb increment in NO
; 95% CI -0.02 to 0.92, p = 0.06). Associations of ambient fine particulate matter (PM
), NO
and NO
concentrations with progression of HAAs varied by race/ethnicity (p = 0.002, 0.007, 0.04, respectively, for interaction) and were strongest among non-Hispanic white people.We conclude that ambient air pollution exposures were associated with subclinical ILD.
Details
- Title: Subtitle
- Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study
- Creators
- Coralynn Sack - Dept of Medicine, University of Washington, Seattle, WA, USASverre Vedal - Dept of Epidemiology, University of Washington, Seattle, WA, USALianne Sheppard - Dept of Biostatistics, University of Washington, Seattle, WA, USAGanesh Raghu - Dept of Medicine, Center for Interstitial Lung Diseases, University of Washington Medical Center, Seattle, WA, USAR Graham Barr - Dept of Epidemiology, Columbia University Medical Center, New York, NY, USAAnna Podolanczuk - Dept of Medicine, Columbia University Medical Center, New York, NY, USABrent Doney - Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USAEric A Hoffman - Dept of Radiology, Carver School of Medicine, University of Iowa, Iowa City, IA, USAAmanda Gassett - Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USAKaren Hinckley-Stukovsky - Dept of Biostatistics, University of Washington, Seattle, WA, USAKayleen Williams - Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USASteve Kawut - Depts of Medicine and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USADavid J Lederer - Both authors contributed equallyJoel D Kaufman - Both authors contributed equally
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.50(6), pp.1700559-1700559
- Publisher
- England
- DOI
- 10.1183/13993003.00559-2017
- PMID
- 29217611
- PMCID
- PMC5726423
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- N01HC95169 / NHLBI NIH HHS N01 HC095160 / NHLBI NIH HHS CC999999 / Intramural CDC HHS N01HC95161 / NHLBI NIH HHS N01 HC095168 / NHLBI NIH HHS N01 HC095165 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS P50 ES015915 / NIEHS NIH HHS N01HC95167 / NHLBI NIH HHS N01 HC095162 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS R01 HL103676 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS N01 HC095166 / NHLBI NIH HHS N01 HC095163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS N01 HC095164 / NHLBI NIH HHS K24 ES013195 / NIEHS NIH HHS R01 HL093081 / NHLBI NIH HHS T32 HL007287 / NHLBI NIH HHS N01 HC095169 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS N01 HC095159 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS N01 HC095161 / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS K24 HL131937 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS P30 ES007033 / NIEHS NIH HHS N01HC95162 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051564602771
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