Logo image
Back
Air trapping and airflow obstruction in newborn cystic fibrosis piglets
Journal article   Open access   Peer reviewed

Air trapping and airflow obstruction in newborn cystic fibrosis piglets

Ryan J Adam, Andrew S Michalski, Christian Bauer, Mahmoud H Abou Alaiwa, Thomas J Gross, Maged S Awadalla, Drake C Bouzek, Nicholas D Gansemer, Peter J Taft, Mark J Hoegger, …
American journal of respiratory and critical care medicine, Vol.188(12), pp.1434-1441
12/15/2013
DOI: 10.1164/rccm.201307-1268OC
PMCID: PMC3917378
PMID: 24168209
url
https://doi.org/10.1164/rccm.201307-1268OCView
Published (Version of record) Open Access

Abstract

Air trapping and airflow obstruction are being increasingly identified in infants with cystic fibrosis. These findings are commonly attributed to airway infection, inflammation, and mucus buildup. To learn if air trapping and airflow obstruction are present before the onset of airway infection and inflammation in cystic fibrosis. On the day they are born, piglets with cystic fibrosis lack airway infection and inflammation. Therefore, we used newborn wild-type piglets and piglets with cystic fibrosis to assess air trapping, airway size, and lung volume with inspiratory and expiratory X-ray computed tomography scans. Micro-computed tomography scanning was used to assess more distal airway sizes. Airway resistance was determined with a mechanical ventilator. Mean linear intercept and alveolar surface area were determined using stereologic methods. On the day they were born, piglets with cystic fibrosis exhibited air trapping more frequently than wild-type piglets (75% vs. 12.5%, respectively). Moreover, newborn piglets with cystic fibrosis had increased airway resistance that was accompanied by luminal size reduction in the trachea, mainstem bronchi, and proximal airways. In contrast, mean linear intercept length, alveolar surface area, and lung volume were similar between both genotypes. The presence of air trapping, airflow obstruction, and airway size reduction in newborn piglets with cystic fibrosis before the onset of airway infection, inflammation, and mucus accumulation indicates that cystic fibrosis impacts airway development. Our findings suggest that early airflow obstruction and air trapping in infants with cystic fibrosis might, in part, be caused by congenital airway abnormalities.
 Airway Obstruction - etiology Multidetector Computed Tomography Pulmonary Alveoli - pathology Cystic Fibrosis - physiopathology Airway Obstruction - congenital Bronchi - physiopathology Cystic Fibrosis - pathology Trachea - diagnostic imaging Airway Resistance Cystic Fibrosis - diagnostic imaging Lung Volume Measurements Trachea - pathology Bronchography - methods Animals Swine Airway Obstruction - diagnostic imaging Airway Obstruction - pathology Trachea - physiopathology Pulmonary Alveoli - physiopathology Bronchi - pathology

Details

Metrics

40 Record Views
57 Times Cited - Web of Science
Logo image