Journal article
Airborne infectious disease and the suppression of pulmonary bioaerosols
Drug discovery today, Vol.11(1-2), pp.51-57
01/2006
DOI: 10.1016/S1359-6446(05)03687-1
PMCID: PMC7108402
PMID: 16478691
Abstract
Airborne pathogens generated from the lungs of an infected individual have three potential outcomes: pathogen aspiration, large droplets expelled, pathogen-infected droplet nuclei.
The current understanding of airborne pathogen spread in relation to the new methods of suppressing exhaled bioaerosols using safe surface-active materials, such as isotonic saline, is reviewed here. We discuss the physics of bioaerosol generation in the lungs, what is currently known about the relationship between expired bioaerosols and airborne infectious disease and current methods of airborne infectious disease containment. We conclude by reviewing recent experiments that suggest the delivery of isotonic saline can significantly diminish exhaled aerosol – generated from airway lining fluid in the course of natural breathing. We also discuss these implications in relation to airborne infectious disease control.
Details
- Title: Subtitle
- Airborne infectious disease and the suppression of pulmonary bioaerosols
- Creators
- Jennifer Fiegel - Harvard UniversityRobert Clarke - Pulmatrix (United States)David A Edwards - Harvard University
- Resource Type
- Journal article
- Publication Details
- Drug discovery today, Vol.11(1-2), pp.51-57
- DOI
- 10.1016/S1359-6446(05)03687-1
- PMID
- 16478691
- PMCID
- PMC7108402
- NLM abbreviation
- Drug Discov Today
- ISSN
- 1359-6446
- eISSN
- 1878-5832
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 01/2006
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering
- Record Identifier
- 9984197100002771
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