Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages
Abstract
Details
- Title: Subtitle
- Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages
- Creators
- Tristan KooistraBorja SaezMarly RocheAlejandro Egea-ZorrillaDongzhu LiDilanjan AnketellNhan NguyenJorge VilloriaJacob GillisEva Petri - Universidad de NavarraLaura Vera - Universidad de NavarraZuriñe Blasco-IturriNeal P Smith - Harvard Medical SchoolJehan AlladinaYanting Zhang - Harvard Medical SchoolVladimir VinarskyManjunatha ShivarajuSusan L ShengMichelle ChenMeryem Gonzalez-CeleiroHongmei MouAvinash WaghrayBrian LinAzadeh PaksaKilangsungla YangerPurushotama Rao TataRui ZhaoBenjamin CaustonJavier J Zulueta - Clinica Universidad de NavarraFelipe ProsperJosalyn L Cho - University of IowaAlexandra-Chloe Villani - Harvard Medical SchoolAdam Haber - Harvard Medical SchoolJayaraj RajagopalBenjamin D MedoffAna Pardo-Saganta
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.44(6), 115860
- DOI
- 10.1016/j.celrep.2025.115860
- PMID
- 40512621
- PMCID
- PMC12286423
- NLM abbreviation
- Cell Rep
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Publisher
- CELL PRESS
- Grant note
- Gobierno de Navarra: GNS80/2016 FEDER
We thank Adam Glick for providing the CK5rtTA mice, Brigid Hogan for providing CK5-creER mice, Alea A. Mills for kindly sharing the p63 foxed mice, Rafi Kopan for the Dll1 foxed mice, and Yibin Kang and Hans Clevers for the Dll1-mCherry mice. We also thank Barry Stripp for providing the goat anti-SCGB1A1 antibody. We wish to extend our thanks to all of the current and former members of the Rajagopal Laboratory, the Medoff Laboratory, the Pardo-Saganta Lab, people involved in the maintenance of mouse colonies, the CIMA and HSCI flow cytometry core facility, the histology core at MGH and CIMA, the UGMLC Giessen Biobank, and all the colleagues that provided their feedback, especially Carrie Sokol and Mikael Pittet for their comments, guidance, and help in the presentation of the results.This research was supported by the New York Stem Cell Foundation (J.R. is a New York Stem Cell Foundation-Robertson Investigator) ; by a National Institutes of Health-National Heart, Lung, and Blood Institute Early Career Research New Faculty (P30) award (5P30HL101287-02) ; RO1s (RO1HL118185 and RO1HL164563) from NIH-NHLBI (to J.R.) ; a Harvard Stem Cell Institute (HSCI) Junior Investigator Grant (to J.R.) ; a grant from the Department of Defense (W81XWH) and a Sanofi iAward to B.D.M.; an NIH-NHLBI grant T32HL116275 and American Thoracic Society Award to T.K.; a grant from Instituto de Salud Carlos III ISCIII (PI17/01346) , co-funded by ERDF,"A way to make Europe" (to B.S.) ; an AEFAT award (to B.S.) ; an AECC Junior Investigator Grant exp. AIO16163636SAEZ (to B.S.) ; a Ramon y Cajal Award RYC-2015-18580 co-funded by FSE (to A.P-S.) ; a grant from Gobierno de Espana SAF2017-89908-R (MINECO/AEI/FEDER, UE.) (toA.P.-S.) ; and a grant from Gobierno de Navarra GNS80/2016 co-funded by FEDER (to A.P.-S.).
- Language
- English
- Date published
- 06/12/2025
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984829025502771