Journal article
Airway tree caliber heterogeneity and airflow obstruction among older adults
Journal of applied physiology (1985), Vol.136(5), pp.1144-1156
02/29/2024
DOI: 10.1152/japplphysiol.00694.2022
PMCID: PMC11368514
PMID: 38420676
Abstract
Smaller mean airway tree caliber is associated with airflow obstruction and chronic obstructive pulmonary disease (COPD). We investigated whether airway tree caliber heterogeneity was associated with airflow obstruction and COPD.
Two community-based cohorts (MESA Lung, CanCOLD) and a longitudinal case-control study of COPD (SPIROMICS) performed spirometry and computed tomography measurements of airway lumen diameters at standard anatomic locations and total lung volume. Percent-predicted airway lumen diameters were calculated using sex-specific reference equations accounting for age, height and lung volume. The association of airway tree caliber heterogeneity, quantified as the standard deviation (SD) of percent-predicted airway lumen diameters, with baseline forced expired volume in 1-second (FEV
), FEV
/forced vital capacity (FEV
/FVC) and COPD, as well as longitudinal spirometry, were assessed using regression models adjusted for age, sex, height, race-ethnicity, and mean airway tree caliber.
Among 2,505 MESA Lung participants (mean±SD age: 69±9 years; 53% female, mean airway tree caliber: 99±10% predicted, airway tree caliber heterogeneity: 14±5%; median follow-up: 6.1 years), participants in the highest quartile of airway tree caliber heterogeneity exhibited lower FEV
(adjusted mean difference: -125 ml, 95%CI:-171,-79), lower FEV
/FVC (adjusted mean difference: -0.01, 95%CI:-0.02,-0.01), and higher odds of COPD (adjusted OR 1.42, 95%CI:1.01-2.02) when compared with the lowest quartile, whereas longitudinal changes in FEV
and FEV
/FVC did not differ significantly. Observations in CanCOLD and SPIROMICS were consistent.
Among older adults, airway tree caliber heterogeneity was associated with airflow obstruction and COPD at baseline but was not associated with longitudinal changes in spirometry.
Details
- Title: Subtitle
- Airway tree caliber heterogeneity and airflow obstruction among older adults
- Creators
- Motahareh Vameghestahbanati - McGill UniversityLeina Kingdom - McGill UniversityEric A Hoffman - University of IowaMiranda Kirby - Toronto Metropolitan UniversityNorrina B Allen - Northwestern MedicineElsa Angelini - Imperial College Healthcare NHS TrustAlain Bertoni - Wake Forest UniversityQutayba Hamid - University of SharjahJames C Hogg - University of British ColumbiaDavid R Jacobs Jr - University of MinnesotaAndrew Laine - Columbia UniversityFrançois Maltais - Université LavalErin D Michos - Johns Hopkins MedicineCoralynn Sack - University of WashingtonDon Sin - University of British ColumbiaKarol E Watson - University of California, Los AngelesArtur Wysoczanksi - Columbia UniversityDavid Couper - University of North Carolina Health CareChristopher Cooper - University of California, Los AngelesMeiLan Han - University of MichiganPrescott Woodruff - University of California, San FranciscoWan C Tan - University of British ColumbiaJean Bourbeau - McGill UniversityR Graham Barr - Columbia UniversityBenjamin M Smith - McGill University
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.136(5), pp.1144-1156
- DOI
- 10.1152/japplphysiol.00694.2022
- PMID
- 38420676
- PMCID
- PMC11368514
- NLM abbreviation
- J Appl Physiol (1985)
- eISSN
- 1522-1601
- Publisher
- American Physiological Society
- Grant note
- HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) COPD Foundation (Chronic Obstructive Pulmonary Disease Foundation) HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) American Lung Association (ALA)
- Language
- English
- Electronic publication date
- 02/29/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984562759402771
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