Journal article
Akkermansia muciniphila attenuates the association between specific metal exposures during pregnancy and depressive symptoms in late childhood
iScience, Vol.27(12), 111335
12/2024
DOI: 10.1016/j.isci.2024.111335
PMCID: PMC11617302
PMID: 39640590
Abstract
Emerging research suggests that exposures to metals during pregnancy and consequent disruptions in gut microbiome (GM) are associated with depressive disorders in childhood. Akkermansia muciniphila, a GM bacteria, has been studied for its potential antidepressant effects. However, its role in influencing the association between prenatal metal exposures and depressive symptoms during childhood is unknown. Leveraging a well-characterized pediatric birth cohort and its microbiome substudy (n=112), we investigated whether a certain subgroup of children at 9-11-year-of-age (characterized by a specific pattern of prenatal exposure to groups of metals or metal-clique) had worsened depressive symptoms and if the presence of A.muciniphila in GM modifies this association. A subgroup of children characterized by the prenatal metal-clique signature of Zinc-Chromium-Cobalt had significantly increased depression scores; however, within that subgroup, children with A.muciniphila had much lower depression scores than those without A.muciniphila in the gut microbiome. Our analysis provides exploratory evidence hypothesizing A.muciniphila as an intervention attenuating the effect of prenatal metal-exposures-associated depressive disorders in late childhood.
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•Metal exposures during pregnancy may affect depression symptoms in childhood•Presence of Akkermansia muciniphila is associated with lower depression symptoms•Akkermansia muciniphila may modify metal-exposures-associated depressive symptoms
Details
- Title: Subtitle
- Akkermansia muciniphila attenuates the association between specific metal exposures during pregnancy and depressive symptoms in late childhood
- Creators
- Vishal Midya - Icahn School of Medicine at Mount SinaiKiran Nagdeo - Icahn School of Medicine at Mount SinaiJamil M. Lane - Icahn School of Medicine at Mount SinaiLibni A. Torres-Olascoaga - Instituto Nacional de Salud PúblicaGabriela Gil Martínez - Instituto Nacional de Salud PúblicaMegan K. Horton - Icahn School of Medicine at Mount SinaiNia McRae - Icahn School of Medicine at Mount SinaiInessa Lopez - Icahn School of Medicine at Mount SinaiJulio Landero - Icahn School of Medicine at Mount SinaiChris Gennings - Icahn School of Medicine at Mount SinaiMartha Maria Téllez-Rojo - Instituto Nacional de Salud PúblicaRobert O. Wright - Icahn School of Medicine at Mount SinaiManish Arora - Icahn School of Medicine at Mount SinaiShoshannah Eggers - Icahn School of Medicine at Mount Sinai
- Resource Type
- Journal article
- Publication Details
- iScience, Vol.27(12), 111335
- DOI
- 10.1016/j.isci.2024.111335
- PMID
- 39640590
- PMCID
- PMC11617302
- NLM abbreviation
- iScience
- ISSN
- 2589-0042
- eISSN
- 2589-0042
- Publisher
- Elsevier Inc
- Grant note
- Clinical and Translational Science Awards (CTSA): UL1TR004419 Na-tional Center for Advancing Translational SciencesOffice of Research Infrastructure of the National Institutes of Health: S10OD026880, S10OD030463 National Institute of Envi-ronmental Health Sciences: R00ES032884, P30ES023515, R01ES013744, R35ES030435, U2CES026555
The authors would like to acknowledge the entire PROGRESS study team, as well as the participants. We would also like to thank Jeremiah Faith and the Microbiome Translational Center at the Icahn School of Medicine at Mount Sinai. Additionally, this work was supported in part through the computational and data resources and staff expertise provided by Scientific Computing and Data at the Icahn School of Medicine at Mount Sinai and supported by the Clinical and Translational Science Awards (CTSA) grant UL1TR004419 from the National Center for Advancing Translational Sciences. Research reported in this publication was also supported by the Office of Research Infrastructure of the National Institutes of Health under award numbers S10OD026880 and S10OD030463. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was supported by the National Institute of Environmental Health Sciences (R00ES032884, P30ES023515, R01ES013744, R35ES030435, U2CES026555) .
- Language
- English
- Electronic publication date
- 11/2024
- Date published
- 12/2024
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984746138602771
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