Journal article
Akt1 in the cardiovascular system: friend or foe?
The Journal of clinical investigation, Vol.115(8), pp.2059-2064
08/2005
DOI: 10.1172/JCI25900
PMCID: PMC1180557
PMID: 16075047
Abstract
Akt is an important signaling molecule that modulates many cellular processes such as cell growth, survival, and metabolism. Akt activation has been proposed as a potential strategy for increasing cardiomyocyte survival following ischemia. In mammalian cells, 3 distinct isoforms of Akt exist, but their precise roles in cardiovascular biology were previously unknown. Three separate studies published in this issue of the JCI now provide important new insight into the central role of Akt1 in the regulation of angiogenesis and the maladaptive or deleterious consequences of chronic unregulated Akt activation in the heart (see the related articles beginning on pages 2108, 2119, and 2128). Here we discuss the implications of these exciting new studies.
Details
- Title: Subtitle
- Akt1 in the cardiovascular system: friend or foe?
- Creators
- Brian T O'Neill - Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USAE Dale Abel
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.115(8), pp.2059-2064
- Publisher
- United States
- DOI
- 10.1172/JCI25900
- PMID
- 16075047
- PMCID
- PMC1180557
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Grant note
- HL 73167 / NHLBI NIH HHS U01 HL070525 / NHLBI NIH HHS R01 HL070070 / NHLBI NIH HHS HL 70525 / NHLBI NIH HHS R01 HL073167 / NHLBI NIH HHS HL 70070 / NHLBI NIH HHS
- Language
- English
- Date published
- 08/2005
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024546102771
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