Journal article
Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
The American journal of cardiology, Vol.121(10), pp.1162-1168
05/15/2018
DOI: 10.1016/j.amjcard.2018.01.042
PMCID: PMC6734183
PMID: 29580627
Abstract
Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of <= 0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at >= 3 days/week was associated with lower CAD risk compared with <= 1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk. Published by Elsevier Inc.
Details
- Title: Subtitle
- Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
- Creators
- Rebecca J. Song - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAXuan-Mai T. Nguyen - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USARachel Quaden - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAYuk-Lam Ho - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAAmy C. Justice - Yale UniversityDavid R. Gagnon - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAKelly Cho - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAChristopher J. O'Donnell - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAJohn Concato - Yale UniversityJ. Michael Gaziano - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USALuc Djousse - VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02130 USAVA Million Veteran Program
- Contributors
- Zuhair K Ballas (Contributor) - University of Iowa, Immunology
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.121(10), pp.1162-1168
- DOI
- 10.1016/j.amjcard.2018.01.042
- PMID
- 29580627
- PMCID
- PMC6734183
- NLM abbreviation
- Am J Cardiol
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- Million Veteran Program, Office of Research and Development, Veterans Health Administration, Washington D.C. I01-CX001025 / VA Merit Award; US Department of Veterans Affairs G002 / CSP I01BX003340 / Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 05/15/2018
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984360046802771
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