Journal article
Alcohol Use Intensity Decreases in Response to Successful Smoking Cessation Therapy
Genes, Vol.13(1), p.2
01/01/2022
DOI: 10.3390/genes13010002
PMCID: PMC8775089
PMID: 35052343
Abstract
Smokers frequently drink heavily. However, the effectiveness of smoking cessation therapy for those with comorbid alcohol abuse is unclear, and the content of smoking cessation programs often does not address comorbid alcohol consumption. In order to achieve a better understanding of the relationship between changes in rate of smoking to the change in intensity of alcohol consumption, and the necessity for alcohol-specific programming for dual users, we quantified cigarette and alcohol consumption in 39 subjects undergoing a 3-month contingency management smoking cessation program using recently developed DNA methylation tools. Intake alcohol consumption, as quantified by the Alcohol T Score (ATS), was highly correlated with cg05575921 smoking intensity (adjusted R-2 = 0.49) with 19 of the 39 subjects having ATS scores indicative of Heavy Alcohol Consumption. After 90 days of smoking cessation therapy, ATS values decreased with the change in ATS score being highly correlated with change in cg05575921 smoking intensity (adjusted R-2 = 0.60), regardless of whether or not the subject managed to completely quit smoking. We conclude that alcohol consumption significantly decreases in response to successful smoking cessation. Further studies to determine whether targeted therapy focused on comorbid alcohol use increases the success of smoking cessation in those with dual use should be explored.
Details
- Title: Subtitle
- Alcohol Use Intensity Decreases in Response to Successful Smoking Cessation Therapy
- Creators
- Robert Philibert - University of IowaKelsey Dawes - University of IowaWillem Philibert - University of IowaAllan M. Andersen - University of IowaEric A. Hoffman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Genes, Vol.13(1), p.2
- DOI
- 10.3390/genes13010002
- PMID
- 35052343
- PMCID
- PMC8775089
- NLM abbreviation
- Genes (Basel)
- ISSN
- 2073-4425
- eISSN
- 2073-4425
- Publisher
- Mdpi
- Number of pages
- 8
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 5R01HL130883, R44CA213507
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984280865002771
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