Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study

Mary C Playdon; Sally B Coburn; Steven C Moore; Louise A Brinton; Nicolas Wentzensen; Garnet Anderson; Robert Wallace; Roni T Falk; Ruth Pfeiffer; Xia Xu; Britton Trabert

doi:10.1038/bjc.2017.419

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Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study

Journal article

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Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study

Mary C Playdon, Sally B Coburn, Steven C Moore, Louise A Brinton, Nicolas Wentzensen, Garnet Anderson, Robert Wallace, Roni T Falk, Ruth Pfeiffer, Xia Xu, …

British journal of cancer, Vol.118(3), pp.448-457

02/06/2018

DOI: 10.1038/bjc.2017.419

PMCID: PMC5808032

PMID: 29235567

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Abstract

Alcohol consumption is associated with an increased risk of several cancers. Potential mechanisms include altered oestrogen metabolism. Parent oestrogens metabolise into alternate pathways of oestrogen metabolites that may have variable effects on cancer pathogenesis. We examined associations of alcohol consumption with circulating oestrogen/oestrogen metabolites in postmenopausal women in the Women's Health Initiative (WHI)-Observational Study (OS). We conducted a cross-sectional analysis of prediagnosis ovarian/endometrial cancer case-control data within WHI-OS (N=1864). Alcohol consumption was measured by validated food frequency questionnaire. Fasting serum parent oestrogens/oestrogen metabolites were assayed using liquid chromatography tandem mass-spectrometry. Geometric mean analyte concentrations (GM, pmol l ) were calculated by alcohol category using inverse-probability weighted linear regression, adjusting for venepuncture age/year, race, smoking, body mass index, years since menopause, oral contraceptive duration, caffeine intake, and physical activity. There was evidence for a positive association between alcohol consumption and oestrone, oestradiol and 2-hydroxylation oestrogen metabolite concentrations among menopausal hormone therapy (MHT) users. We observed an association between liquor consumption and parent oestrogens among non-MHT users, who consumed larger doses of liquor than MHT users. Among postmenopausal women, the association between alcohol intake and parent oestrogen, but not oestrogen metabolite concentrations, may be influenced by MHT and type of alcohol.

Aged

Alcohol Drinking - blood

Case-Control Studies

Cross-Sectional Studies

Endometrial Neoplasms - blood

Endometrial Neoplasms - diagnosis

Estradiol - blood

Estrogen Replacement Therapy

Estrogens - blood

Estrogens - metabolism

Estrone - blood

Female

Humans

Middle Aged

Ovarian Neoplasms - blood

Ovarian Neoplasms - diagnosis

Postmenopause - blood

Surveys and Questionnaires

Details

Title: Subtitle: Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study
Creators: Mary C Playdon - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Sally B Coburn - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Steven C Moore - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Garnet Anderson - University of Washington
Robert Wallace - University of Iowa
Roni T Falk - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Ruth Pfeiffer - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Xia Xu - Leidos Biomedical Research Inc. (United States)
Britton Trabert - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6909 Medical Centre Drive, Rockville, MD 20850, USA.
Resource Type: Journal article
Publication Details: British journal of cancer, Vol.118(3), pp.448-457
DOI: 10.1038/bjc.2017.419
PMID: 29235567
PMCID: PMC5808032
NLM abbreviation: Br J Cancer
ISSN: 0007-0920
eISSN: 1532-1827
Grant note: HHSN268201100046C / NHLBI NIH HHS HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100003C / WHI NIH HHS P30 CA086862 / NCI NIH HHS HHSN268201100004C / WHI NIH HHS
Language: English
Date published: 02/06/2018
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984364400302771

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