Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

B C-H Chiu; J R Cerhan; S M Gapstur; T A Sellers; W Zheng; C T Lutz; R B Wallace; J D Potter

doi:10.1038/sj.bjc.6690547

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Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

Journal article

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Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women

B C-H Chiu, J R Cerhan, S M Gapstur, T A Sellers, W Zheng, C T Lutz, R B Wallace and J D Potter

British journal of cancer, Vol.80(9), pp.1476-1482

07/01/1999

DOI: 10.1038/sj.bjc.6690547

PMCID: PMC2363074

PMID: 10424754

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Abstract

We investigated the relation of alcohol consumption to risk of non-Hodgkin's lymphoma (NHL) in a cohort of 35 156 lowa women aged 55–69 years who participated in the lowa Women's Health Study in 1986. Alcohol consumption at baseline was obtained using a mailed questionnaire. During the 9-year follow-up period, 143 incident cases of NHL were identified. Higher alcohol consumption was significantly associated with a decreased risk of NHL ( P -trend = 0.03). Compared to non-drinkers, multivariate-adjusted relative risks (RRs) were decreased for women with intake of ≤ 3.4 g day −1 (RR = 0.78; 95% confidence interval (CI) 0.51–1.21) and > 3.4 g day −1 (RR = 0.59; 0.36–0.97). The inverse association could not be attributed to one particular type of alcoholic beverage, although red wine (RR = 0.21 for > 2 glasses per month vs non-drinker; 0.05–0.86; P -trend = 0.02) has the most distinct effect. The apparent protective effect was universal regardless of specific NHL grade or Working Formulation subtype, but was most pronounced for nodal NHL (RR = 0.48; 0.26–0.90; P -trend = 0.01) and low-grade NHL (RR = 0.52; 0.21–1.26; P -trend = 0.05). These data suggest that moderate alcohol consumption is inversely associated with the risk of NHL in older women and the amount of alcohol consumed, rather than the type of alcoholic beverages, appears to be the main effect determinant. © 1999 Cancer Research Campaign

alcohol

cohort study

lymphoma

non-Hodgkin

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Details

Title: Subtitle: Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women
Creators: B C-H Chiu - University of Iowa
J R Cerhan - Department of Preventive Medicine and Environmental Health, The University of lowa College of Medicine, lowa City, USA
S M Gapstur - Northwestern University
T A Sellers - Mayo Clinic Rochester, MN
W Zheng - University of South Carolina
C T Lutz - University of Iowa
R B Wallace - University of Iowa
J D Potter - Fred Hutch Cancer Center
Resource Type: Journal article
Publication Details: British journal of cancer, Vol.80(9), pp.1476-1482
DOI: 10.1038/sj.bjc.6690547
PMID: 10424754
PMCID: PMC2363074
NLM abbreviation: Br J Cancer
ISSN: 0007-0920
eISSN: 1532-1827
Publisher: Nature Publishing Group
Language: English
Date published: 07/01/1999
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984364460002771

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