Journal article
Alcohol consumption and serum metabolite concentrations in young women
Cancer causes & control, Vol.31(2), pp.113-126
02/2020
DOI: 10.1007/s10552-019-01256-1
PMCID: PMC7008965
PMID: 31828464
Abstract
Alcohol consumption is an established breast cancer risk factor, though further research is needed to advance our understanding of the mechanism underlying the association. We used global metabolomics profiling to identify serum metabolites and metabolic pathways that could potentially mediate the alcohol-breast cancer association.
A cross-sectional analysis of reported alcohol consumption and serum metabolite concentrations was conducted among 211 healthy women 25-29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-Up Study (DISC06). Alcohol-metabolite associations were evaluated using multivariable linear mixed-effects regression.
Alcohol was significantly (FDR p < 0.05) associated with several serum metabolites after adjustment for diet composition and other potential confounders. The amino acid sarcosine, the omega-3 fatty acid eicosapentaenoate, and the steroid 4-androsten-3beta,17beta-diol monosulfate were positively associated with alcohol intake, while the gamma-tocopherol metabolite gamma-carboxyethyl hydroxychroman (CEHC) was inversely associated. Positive associations of alcohol with 2-methylcitrate and 4-androsten-3beta,17beta-diol disulfate were borderline significant (FDR p < 0.10). Metabolite set enrichment analysis identified steroids and the glycine pathway as having more members associated with alcohol consumption than expected by chance.
Most of the metabolites associated with alcohol in the current analysis participate in pathways hypothesized to mediate the alcohol-breast cancer association including hormonal, one-carbon metabolism, and oxidative stress pathways, but they could also affect risk via alternative pathways. Independent replication of alcohol-metabolite associations and prospective evaluation of confirmed associations with breast cancer risk are needed.
Details
- Title: Subtitle
- Alcohol consumption and serum metabolite concentrations in young women
- Creators
- Joanne F Dorgan - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. jdorgan@som.umaryland.eduSeungyoun Jung - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USACher M Dallal - Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, College Park, MD, 20740, USAMin Zhan - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USAChristina A Stennett - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USAYuji Zhang - Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USARichard L Eckert - Department of Biochemistry, University of Maryland School of Medicine, Baltimore, MD, 21201, USALinda G Snetselaar - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, 52242, USALinda Van Horn - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.31(2), pp.113-126
- DOI
- 10.1007/s10552-019-01256-1
- PMID
- 31828464
- PMCID
- PMC7008965
- NLM abbreviation
- Cancer Causes Control
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Publisher
- Netherlands
- Grant note
- P30 CA134274 / NCI NIH HHS R01 CA104670 / NCI NIH HHS R01CA104670 / US National Institutes of Health
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984066103002771
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