Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck

Donghong Wang; Justine M RITCHIE; Elaine M SMITH; Zugui Zhang; Lubomir P TUREK; Thomas H HAUGEN

doi:10.1158/1055-9965.EPI-04-0343

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Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck

Journal article

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Peer reviewed

Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck

Donghong Wang, Justine M RITCHIE, Elaine M SMITH, Zugui Zhang, Lubomir P TUREK and Thomas H HAUGEN

Cancer epidemiology, biomarkers & prevention, Vol.14(3), pp.626-632

2005

DOI: 10.1158/1055-9965.EPI-04-0343

PMID: 15767341

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Abstract

In order to examine the association between alcohol dehydrogenase 3 (ADH3) genotypes and risk of head and neck squamous cell carcinomas (HNSCC), we conducted a hospital based case-control study including 348 cases and 330 controls. DNA isolated from exfoliated cells from the oral cavity were genotyped for ADH3 polymorphisms using PCR followed by SspI digestion. Odds ratios (OR) and hazards ratios (HR) were done by unconditional logistic regression and Cox regression. Relative to ADH32-2 carriers, ADH31-1 [OR, 0.7; 95% confidence interval (CI), 0.4-1.1] and ADH31-2 (OR, 0.8; 95% CI, 0.5-1.2) had a nonsignificant reduced risk of HNSCC. ADH1-2 smokers of >30 pack-years were at decreased risk of oral cavity squamous cell carcinomas compared with ADH32-2 (OR, 0.3, 0.1-0.9), whereas ADH31-1 smokers were not. After adjustment, those with ADH31-2 had significantly worse overall survival compared with ADH31-1 (HR, 0.3, 0.2-0.6) or ADH32-2 (HR, 0.4, 0.2-0.9) and increased recurrence (ADH31-1, 0.2, 0.1-0.6; ADH32-2, 0.6, 0.2-1.3). Our data did not show that ADH3 genotypes had a significantly independent effect on the risk of HNSCC, nor did they modify the risks increased by alcohol or tobacco consumption and high-risk human papillomavirus infection. However, participants with ADH31-2 genotype were associated with poorer survival compared with those who had the other two ADH3 genotypes and a higher rate of recurrence than participants with ADH31-1 genotype.

Tumors

Biological and medical sciences

Medical sciences

Otorhinolaryngology. Stomatology

Otorhinolaryngology (head neck, general aspects and miscellaneous)

Details

Title: Subtitle: Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck
Creators: Donghong Wang - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United States
Justine M RITCHIE - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, United States
Elaine M SMITH - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United States
Zugui Zhang - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, United States
Lubomir P TUREK - Veterans Affairs Medical Center, Iowa City, Iowa, United States
Thomas H HAUGEN - Veterans Affairs Medical Center, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.14(3), pp.626-632
DOI: 10.1158/1055-9965.EPI-04-0343
PMID: 15767341
NLM abbreviation: Cancer Epidemiol Biomarkers Prev
ISSN: 1055-9965
eISSN: 1538-7755
Publisher: American Association for Cancer Research; Philadelphia, PA
Language: English
Date published: 2005
Academic Unit: Epidemiology; Pathology; Otolaryngology
Record Identifier: 9984047672502771

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