Journal article
Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration
British journal of cancer, Vol.123(9), pp.1456-1463
10/2020
DOI: 10.1038/s41416-020-01031-z
PMCID: PMC7592048
PMID: 32830199
Abstract
Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.
Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.
For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).
Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Details
- Title: Subtitle
- Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration
- Creators
- Gioia Di Credico - Department of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, ItalyJerry Polesel - Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. polesel@cro.itLuigino Dal Maso - Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. epidemiology@cro.itFrancesco Pauli - Department of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, ItalyNicola Torelli - Department of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, ItalyDaniele Luce - Université de Rennes, INSERM, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Pointe-à-Pitre, FranceLoredana Radoï - INSERM UMR 1018, Centre for Research in Epidemiology and Population Health (CESP), Cancer Epidemiology, Genes and Environment Team, Villejuif, FranceKeitaro Matsuo - Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, JapanDiego Serraino - Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyPaul Brennan - International Agency for Research on Cancer, Lyon, FranceIvana Holcatova - Institute of Hygiene & Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech RepublicWolfgang Ahrens - University of Bremen, Faculty of Mathematics and Computer Science, Bremen, GermanyPagona Lagiou - Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceCristina Canova - University of Padua, Padova, ItalyLorenzo Richiardi - Department of Medical Sciences, University of Turin, Turin, ItalyClaire M Healy - Trinity College School of Dental Science, Dublin, IrelandKristina Kjaerheim - Cancer Registry of Norway, Oslo, NorwayDavid I Conway - School of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UKGary J Macfarlane - School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UKPeter Thomson - University of Hong Kong, Hong Kong, ChinaAntonio Agudo - Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, SpainAriana Znaor - International Agency for Research on Cancer, Lyon, FranceSilvia Franceschi - Scientific Directorate, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyRolando Herrero - International Agency for Research on Cancer, Lyon, FranceTatiana N Toporcov - Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, BrazilRaquel A Moyses - Head and Neck Surgery, School of Medicine, University of São Paulo, São Paulo, BrazilJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAEva Negri - Department of Biomedical and Clinical Sciences, University of Milan, Milan, ItalyMarta Vilensky - Instituto de Oncología Ángel H. Roffo, Universidad de Buenos Aires, Buenos Aires, ArgentinaLeticia Fernandez - Institute of Oncology and Radiobiology, Havana, CubaMaria Paula Curado - Epidemiology-CIPE/ACCAMARGO, Sao Paulo, BrazilAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilAlexander W Daudt - Hospital Moinhos de Vento, Porto Alegre, BrazilRosalina Koifman - Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, BrazilVictor Wunsch-Filho - Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, BrazilAndrew F Olshan - Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, USAJose P Zevallos - Division of Head and Neck Surgical Oncology in the Department of Otolaryngology/Head and Neck Surgery at Washington University School of Medicine, St Louis, MO, USAErich M Sturgis - Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USAGuojun Li - Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USAFabio Levi - Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Unisanté, University of Lausanne, Lausanne, SwitzerlandZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USAHal Morgenstern - Departments of Epidemiology and Environmental Health Sciences, School of Public Health and Department of Urology, Medical School, University of Michigan, Ann Arbor, MI, USAElaine Smith - College of Public Health, University of Iowa, Iowa City, IA, USAPhilip Lazarus - Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USACarlo La Vecchia - Branch of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, ItalyWerner Garavello - Department of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca, Monza, ItalyChu Chen - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USAStephen M Schwartz - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USATongzhang Zheng - Department of Epidemiology, Brown University School of Public Health, Providence, RI, USAThomas L Vaughan - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USAKarl Kelsey - Brown University, Providence, Rhode Island, RI, USAMichael McClean - Boston University School of Public Health, Boston, MA, USASimone Benhamou - National Institute of Health and Medical Research, INSERM U1018, Villejuif, FranceRichard B Hayes - Division of Epidemiology, New York University School Of Medicine, New York, NY, USAMark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USAMaura Gillison - "Thoracic/Head and Neck Medical Oncology", The University of Texas MD Anderson Cancer Center, Houston, TX, USAStimson Schantz - New York Eye and Ear Infirmary, New York, NY, USAGuo-Pei Yu - Medical Informatics Center, Peking University, Beijing, ChinaShu-Chun Chuang - Institute of Population Health Sciences, National Health Research Institutes, Miaoli, TaiwanPaolo Boffetta - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAMia Hashibe - Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USAAmy Lee Yuan-Chin - Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USAValeria Edefonti - Branch of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy
- Resource Type
- Journal article
- Publication Details
- British journal of cancer, Vol.123(9), pp.1456-1463
- DOI
- 10.1038/s41416-020-01031-z
- PMID
- 32830199
- PMCID
- PMC7592048
- NLM abbreviation
- Br J Cancer
- ISSN
- 0007-0920
- eISSN
- 1532-1827
- Publisher
- England
- Grant note
- R03 CA113157 / NCI NIH HHS T32 CA009142 / NCI NIH HHS R01 DA011386 / NIDA NIH HHS R01 DA012609 / NIDA NIH HHS R03 DE016611 / NIDCR NIH HHS P01 CA068384 / NCI NIH HHS R03 CA077954 / NCI NIH HHS R21 ES011667 / NIEHS NIH HHS R01 DE013110 / NIDCR NIH HHS P50 CA090388 / NCI NIH HHS R01 DE013158 / NIDCR NIH HHS R01 CA100679 / NCI NIH HHS R01 CA031845 / NCI NIH HHS R01 CA090731 / NCI NIH HHS R01 CA078609 / NCI NIH HHS R01 CA048996 / NCI NIH HHS R01 CA030022 / NCI NIH HHS K07 CA104231 / NCI NIH HHS R01 AG061188 / NIA NIH HHS U01 CA096134 / NCI NIH HHS R01 DA011979 / NIDA NIH HHS
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984066109402771
Metrics
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