Journal article
Alcohol effects on response inhibition: Variability across tasks and individuals
Experimental and clinical psychopharmacology, Vol.26(3), pp.251-267
06/2018
DOI: 10.1037/pha0000190
PMCID: PMC5991490
PMID: 29863383
Abstract
Considerable research has investigated the acute effects of alcohol on response inhibition, but a number of issues remain unresolved. Given that most studies use only a single laboratory task to assess inhibition, it is often difficult to determine whether alcohol's effects are task specific or generalize across measures of the same construct. Moreover, relatively few studies have directly compared effects of alcohol under ascending and descending blood alcohol concentrations (BACs), and those that have often failed to disentangle BAC limb effects from the effects of repeated testing. This study was intended to provide a test of alcohol's effects on behavioral inhibition using multiple laboratory measures in a relatively large sample and comparing effects under ascending and descending BAC. Young adults (N = 216) completed three commonly used inhibition tasks (Stroop, antisaccade, and stop-signal) at baseline and again 1-3 weeks later under one of three beverage conditions (alcohol, placebo or control) and one of two BAC limb conditions (ascending/descending or descending only). Findings indicated considerable specificity in alcohol's effects. Relative to control and placebo conditions, antisaccade performance suffered under both ascending and descending BAC and stop-signal reaction time (RT) suffered only under descending BAC. The Stroop RT interference effect was not affected by alcohol, though alcohol did impair response accuracy on incongruent Stroop trials. Baseline performance moderated effects of alcohol on both antisaccade accuracy and Stroop interference, suggesting the importance of individual differences. The current findings suggest that more specificity is required in characterizing acute effects of alcohol on inhibitory control. (PsycINFO Database Record
Details
- Title: Subtitle
- Alcohol effects on response inhibition: Variability across tasks and individuals
- Creators
- Bruce D Bartholow - Department of Psychological SciencesKimberly A Fleming - Department of Psychological SciencesPhillip K Wood - Department of Psychological SciencesNelson Cowan - Department of Psychological SciencesJ Scott Saults - Department of Psychological SciencesLee Altamirano - Department of Psychology and Neuroscience, University of ColoradoAkira Miyake - Department of Psychology and Neuroscience, University of ColoradoJorge Martins - Department of Psychological SciencesKenneth J Sher - Department of Psychological Sciences
- Resource Type
- Journal article
- Publication Details
- Experimental and clinical psychopharmacology, Vol.26(3), pp.251-267
- DOI
- 10.1037/pha0000190
- PMID
- 29863383
- PMCID
- PMC5991490
- NLM abbreviation
- Exp Clin Psychopharmacol
- ISSN
- 1064-1297
- eISSN
- 1936-2293
- Grant note
- T32 AA013526 / NIAAA NIH HHS F31 AA022551 / NIAAA NIH HHS K05 AA017242 / NIAAA NIH HHS Portuguese Government Fundação para a Ciência e a Tecnologia NIAAA NIH HHS P60 AA011998 / NIAAA NIH HHS
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984446275502771
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