Journal article
Alcohol intake and cigarette smoking and risk of a contralateral breast cancer: The Women's Environmental Cancer and Radiation Epidemiology Study
American journal of epidemiology, Vol.169(8), pp.962-968
04/15/2009
DOI: 10.1093/aje/kwn422
PMCID: PMC2727227
PMID: 19211621
Abstract
Women with primary breast cancer are at increased risk of developing second primary breast cancer. Few studies have evaluated risk factors for the development of asynchronous contralateral breast cancer in women with breast cancer. In the Women's Environmental Cancer and Radiation Epidemiology Study (1985-2001), the roles of alcohol and smoking were examined in 708 women with asynchronous contralateral breast cancer (cases) compared with 1,399 women with unilateral breast cancer (controls). Cases and controls aged less than 55 years at first breast cancer diagnosis were identified from 5 population-based cancer registries in the United States and Denmark. Controls were matched to cases on birth year, diagnosis year, registry region, and race and countermatched on radiation treatment. Risk factor information was collected by telephone interview. Rate ratios and 95% confidence intervals were estimated by using conditional logistic regression. Ever regular drinking was associated with an increased risk of asynchronous contralateral breast cancer (rate ratio = 1.3, 95% confidence interval: 1.0, 1.6), and the risk increased with increasing duration (P = 0.03). Smoking was not related to asynchronous contralateral breast cancer. In this, the largest study of asynchronous contralateral breast cancer to date, alcohol is a risk factor for the disease, as it is for a first primary breast cancer.
Details
- Title: Subtitle
- Alcohol intake and cigarette smoking and risk of a contralateral breast cancer: The Women's Environmental Cancer and Radiation Epidemiology Study
- Creators
- Julia A Knight - Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada. knight@lunenfeld.caLeslie BernsteinJoan LargentMarinela CapanuColin B BeggLene MellemkjaerCharles F LynchKathleen E MaloneAnne S ReinerXiaolin LiangRobert W HaileJohn D Boice JrJonine L BernsteinWECARE Study Collaborative Group
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.169(8), pp.962-968
- Publisher
- United States
- DOI
- 10.1093/aje/kwn422
- PMID
- 19211621
- PMCID
- PMC2727227
- ISSN
- 1476-6256
- eISSN
- 1476-6256
- Grant note
- R01 CA129639 / NCI NIH HHS R01 CA97397 / NCI NIH HHS U01 CA83178 / NCI NIH HHS R01 CA097397 / NCI NIH HHS U01 CA083178 / NCI NIH HHS
- Language
- English
- Date published
- 04/15/2009
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995116102771
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