Journal article
Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women
Cancer prevention research (Philadelphia, Pa.), Vol.4(12), pp.2035-2043
12/2011
DOI: 10.1158/1940-6207.CAPR-11-0276
PMCID: PMC3584678
PMID: 21900595
Abstract
Increased alcohol consumption is a putative colorectal cancer (CRC) risk factor. However, existing data are less conclusive for women than men. Also, to date, relatively few studies have reported alcohol-related CRC risks based on molecularly defined tumor subtypes. We evaluated associations between alcohol intake and incident CRC, overall and by microsatellite instability [MSI high (MSI-H) or MSI low/microsatellite stable (MSI-L/MSS)], CpG island methylator phenotype (CIMP positive or CIMP negative), and BRAF mutation (mutated or wild-type) status in the prospective, population-based Iowa Women's Health Study (IWHS; n = 41,836). Subjects were 55 to 69 years at baseline (1986), and exposure data were obtained by self-report. Incident CRCs were prospectively identified and archived, paraffin-embedded tissue specimens were collected from 732 representative cases, diagnosed through December 31, 2002. Multivariate Cox regression models were fit to estimate relative risks (RR) and 95% confidence intervals (CI). Among alcohol consumers, the median intake (range) was 3.4 (0.9-292.8) g/d. Compared with nonconsumers, alcohol intake levels of 3.4 g/d or less (RR = 1.00; 95% CI, 0.86-1.15) and more than 3.4 g/d (RR = 1.06; 95% CI, 0.91-1.24) were not significantly associated with overall CRC risk. Analyses based on alcohol intake levels of 30 g/d or less and more than 30 g/d or quartile distributions yielded similar risk estimates. Null associations were also observed between each alcohol intake level and the MSI-, CIMP- or, BRAF-defined CRC subtypes (P > 0.05 for each comparison). These data do not support an adverse effect from alcohol intake on CRC risk, overall or by specific molecularly defined subtypes, among older women.
Details
- Title: Subtitle
- Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women
- Creators
- Anthony A Razzak - Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USAAmy S OxentenkoRobert A VierkantLori S TillmansAlice H Wang - Mayo ClinicDaniel J WeisenbergerPeter W LairdCharles F LynchKristin E AndersonAmy J FrenchRobert W HaileLisa J HarnackSusan L SlagerThomas C SmyrkStephen N ThibodeauJames R CerhanPaul J Limburg
- Resource Type
- Journal article
- Publication Details
- Cancer prevention research (Philadelphia, Pa.), Vol.4(12), pp.2035-2043
- Publisher
- United States
- DOI
- 10.1158/1940-6207.CAPR-11-0276
- PMID
- 21900595
- PMCID
- PMC3584678
- ISSN
- 1940-6207
- eISSN
- 1940-6215
- Grant note
- U01 CA074800 / NCI NIH HHS R01 CA107333 / NCI NIH HHS R01 CA039742 / NCI NIH HHS R01 CA39742 / NCI NIH HHS
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995038502771
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