Journal article
Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study
Surgery for obesity and related diseases, Vol.16(4), pp.536-544
04/01/2020
DOI: 10.1016/j.soard.2020.01.014
PMCID: 7141947
PMID: 32075778
Abstract
Background: Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the most common bariatric surgeries performed worldwide, increase the risk to develop an alcohol use disorder. This might be due, in part, to surgery-related changes in alcohol pharmacokinetics. Another risk factor, unexplored within this population, is having a reduced subjective response to alcohol's sedative effects.
Objectives: To assess whether the alcohol sensitivity questionnaire (ASQ), a simple self-report measure, could pinpoint reduced alcohol sensitivity in the bariatric population.
Setting: University medical centers in Missouri and Illinois.
Setting: University medical centers in Missouri and Illinois.
Methods: Women who had RYGB (n = 16), SG (n = 28), or laparoscopic adjustable gastric banding surgery (n = 11) within the last 5 years completed the ASQ for both pre- and postsurgical timeframes, and 45 of them participated in oral alcohol challenge testing postsurgery. Blood alcohol concentration (BAC) and subjective stimulation and sedation were measured before and for 3.5 hours after drinking.
Results: In line with faster and higher peak BACs after RYGB and SG than laparoscopic adjustable gastric banding surgery (P < .001), postsurgery ASQ scores were more reduced from presurgery scores after RYGB/SG than after laparoscopic adjustable gastric banding surgery (-2.3 +/- .3 versus -1.2 +/- .2; P < .05). However, despite the dramatic changes in BAC observed when ingesting alcohol after RYGB/SG surgeries, which resulted in peak BAC that were approximately 50% above the legal driving limit, a third of these women felt almost no alcohol-related sedative effects.
Conclusions: Although RYGB/SG dramatically increased sensitivity to alcohol in all participants, meaningful interindividual differences remained. The ASQ might help identify patients at increased risk to develop an alcohol use disorder after surgery. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study
- Creators
- Maria Belen Acevedo - University of Illinois Urbana-ChampaignMargarita Teran-Garcia - University of Illinois Urbana-ChampaignKathleen K. Bucholz - Washington University in St. LouisJ. Christopher Eagon - Washington University in St. LouisBruce D. Bartholow - University of MissouriNicholas A. Burd - University of Illinois Urbana-ChampaignNaiman Khan - University of Illinois Urbana-ChampaignBlair Rowitz - University of Illinois Urbana-ChampaignMarta Yanina Pepino - University of Illinois Urbana-Champaign
- Resource Type
- Journal article
- Publication Details
- Surgery for obesity and related diseases, Vol.16(4), pp.536-544
- DOI
- 10.1016/j.soard.2020.01.014
- PMID
- 32075778
- PMCID
- 7141947
- NLM abbreviation
- Surg Obes Relat Dis
- ISSN
- 1550-7289
- eISSN
- 1878-7533
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- AA 020018; AA 024103; DK 56341 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 698-921 / USDA National Institute of Food and Agriculture Hatch Project
- Language
- English
- Date published
- 04/01/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984446525802771
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