Journal article
Alcohol use and HIV pharmacotherapy
AIDS research and human retroviruses, Vol.18(11), pp.757-770
2002
DOI: 10.1089/08892220260139495
PMID: 12167267
Abstract
Alcohol consumption by individuals infected with HIV is an important medical management issue with significant implications for the effectiveness of antiretroviral therapy as well as an important evolving field of HIV research. Alcohol consumption is a risk factor for poor medication adherence and can modify liver drug metabolism, both of which can lead to the emergence of drug-resistant virus. Research indicates that alcohol consumption greater than 50 g/day (four or five drinks) is a risk factor for liver disease progression among patients with HIV/HCV coinfection. In addition, alcohol-induced cirrhosis can result in changes in drug metabolism in the liver through compromised liver function. More research studies are needed to elucidate the biological and molecular basis of the clinical changes induced by alcohol consumption in HIV-infected individuals and on the relationship of these changes to the effectiveness of HIV pharmacotherapy. Specifically, research areas that are of particular importance are (1) determining alcohol consumption levels and patterns and its impact on antiretroviral medication adherence, efficacy, and physician prescribing practices; (2) identifying behavioral interventions to enhance adherence to HIV medications and reduce alcohol consumption; (3) clarifying the relationships and interactions among alcohol metabolism, HIV drug metabolism, and pharmacogenetics; (4) elucidating the extent of liver toxicity due to antiretroviral therapy and drug-drug interactions in individuals who consume alcohol; and (5) delineating the contribution of alcohol consumption to end-stage organ damage, particularly in HIV/HCV coinfection.
Details
- Title: Subtitle
- Alcohol use and HIV pharmacotherapy
- Creators
- Thomas F KRESINA - National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, United StatesCharles W FLEXNER - Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesJacqueline SINCLAIR - Veterans Affairs Medical Center and Dartmouth Medical School, Hanover, New Hampshire 03755, United StatesMaria ALMIRA CORREIA - University of California, San Francisco School of Medicine, San Francisco, California 94143, United StatesJack T STAPLETON - Veterans Affairs Medical Center and University of Iowa, Iowa City, Iowa 52246, United StatesSamuel ADENIYI-JONES - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United StatesVictoria CARGILL - Office of AIDS Research, National Institutes of Health, Bethesda, Maryland 20892, United StatesLaura W CHEEVER - HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, Maryland 20857, United States
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.18(11), pp.757-770
- Publisher
- Liebert
- DOI
- 10.1089/08892220260139495
- PMID
- 12167267
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 2002
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094318202771
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