Journal article
Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample
Psychology of addictive behaviors, Vol.36(4), pp.364-374
05/26/2022
DOI: 10.1037/adb0000840
PMCID: PMC9247836
PMID: 35617219
Abstract
To examine associations between alcohol use disorder (AUD), its psychiatric comorbidities, and their interactions, with marital outcomes in a diverse high-risk, genetically informative sample.
Participants included European ancestry (EA;
= 4,045) and African ancestry (AA;
= 1,550) individuals from the multigenerational Collaborative Study on the Genetics of Alcoholism (COGA) sample (56% female,
∼ 41 years). Outcomes were lifetime marriage and divorce. Predictors included lifetime AUD, an alcohol problems polygenic score (PRS), and AUD comorbidities, including conduct or antisocial personality disorder (ASP), cannabis dependence/abuse (CAN), frequent tobacco use (TOB), and major depressive disorder (MDD). Mixed effect Cox models and generalized linear mixed effects models were fit.
Among EA participants, those with AUD and CAN were less likely to marry (hazard ratios [HRs] 0.70-0.83,
s < 0.01). Among AA participants, those with AUD and TOB were less likely to marry (HRs 0.66-0.82,
s < 0.05) and those with MDD were more likely to marry (HR = 1.34,
s < 0.01). Among EA participants, AUD, CAN, TOB, and MDD were associated with higher odds of divorce (odds ratios [ORs] 1.59-2.21,
s < 0.01). Among AA participants, no predictors were significantly associated with divorce. Significant random effects indicated genetic and environmental influences on marriage, but only environmental factors on divorce.
In a high-risk sample, AUD was associated with reduced likelihood of marriage in EA and AA individuals and increased risk of divorce in EA individuals. These associations were largely independent of comorbidities. Genetic and environmental background factors contributed to marriage, while only environmental background factors contributed to divorce. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Details
- Title: Subtitle
- Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample
- Creators
- Nathaniel S Thomas - Department of Psychology.Sally I-Chun Kuo - Department of Psychiatry.Fazil Aliev - Department of Psychiatry.Vivia V McCutcheon - Department of Psychiatry.Jacquelyn M Meyers - Department of Psychiatry and Behavioral Sciences.Grace Chan - Department of Psychiatry.Victor Hesselbrock - Department of Psychiatry.Chella Kamarajan - Department of Psychiatry and Behavioral Sciences.Sivan Kinreich - Department of Psychiatry and Behavioral Sciences.John R Kramer - Department of Psychiatry.Samuel Kuperman - Department of Psychiatry.Dongbing Lai - Department of Medical and Molecular Genetics.Martin H Plawecki - Department of Psychiatry.Bernice Porjesz - Department of Psychiatry and Behavioral Sciences.Marc A Schuckit - Department of Medical and Molecular Genetics.Danielle M Dick - Department of Psychiatry.Kathleen K Bucholz - Department of Psychology.Jessica E Salvatore - Department of Psychology.
- Resource Type
- Journal article
- Publication Details
- Psychology of addictive behaviors, Vol.36(4), pp.364-374
- DOI
- 10.1037/adb0000840
- PMID
- 35617219
- PMCID
- PMC9247836
- NLM abbreviation
- Psychol Addict Behav
- ISSN
- 0893-164X
- eISSN
- 1939-1501
- Grant note
- NIAAA NIH HHS
- Language
- English
- Date published
- 05/26/2022
- Academic Unit
- Psychiatry
- Record Identifier
- 9984293655202771
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