Journal article
Aldehyde dehydrogenase 2 in sporadic Parkinson's disease
Parkinsonism & related disorders, Vol.20(1), pp.S68-S72
01/2014
DOI: 10.1016/S1353-8020(13)70018-X
PMID: 24262192
Abstract
Aldehyde dehydrogenases (ALDH) play a key role in neuronal protection. They exert this function by metabolizing biogenic amine-related aldehydes, e.g. 3,4-dihydroxyphenylacetaldehyde (DOPAL), and by protecting neurons against aldehyde- and oxidative stress-related neurotoxicity. The role of these different isoenzymes has been discussed in other neurodegenerative disorders before. It is somewhat surprising that only few studies have investigated their role in the aetiology of Parkinson's disease (PD), in both the degeneration of dopaminergic neurons and the formation of Lewy bodies. Earlier studies report severe alterations of the cytosolic isoform of ALDH expression (ALDH 1A1) in the substantia nigra of patients with PD. However, there are no data regarding the activity of ALDH 2 located at the inner mitochondrial membrane. Since mitochondrial dysfunctions are hypothesized to be of importance in the aetiology of PD we have examined the enzymatic activity of mitochondrial ALDH 2 in post-mortem putamen and frontal cortex of patients with PD and controls. We found that mitochondrial ALDH 2 activity in contrast to the frontal cortex was significantly increased in the putamen of patients with PD compared to controls.
Details
- Title: Subtitle
- Aldehyde dehydrogenase 2 in sporadic Parkinson's disease
- Creators
- Tanja Maria Michel - Department of Psychiatry and Psychotherapy, Rostock University Medical School, Rostock, GermanyLudwig Käsbauer - University Hospital Wuerzburg, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Wuerzburg, GermanyWieland Gsell - University Hospital Wuerzburg, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Wuerzburg, GermanyJulia Jecel - Department of Neurology, Danube Hospital, Center for Social Medicine East, Vienna, AustriaAbigail Jane Sheldrick - Department of Psychiatry and Psychotherapy, Rostock University Medical School, Rostock, GermanyMiriam Cortese - RWTH Laboratory for Plastic Surgery, RWTH Aachen University, Aachen, GermanyThomas Nickl-Jockschat - Department of Psychiatry and Psychotherapy, Rostock University Medical School, Rostock, GermanyEdna Grünblatt - University Clinic of Child and Adolescent Psychiatry, University of Zurich, Zurich, SwitzerlandPeter Riederer - University Hospital Wuerzburg, Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Wuerzburg, Germany
- Resource Type
- Journal article
- Publication Details
- Parkinsonism & related disorders, Vol.20(1), pp.S68-S72
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S1353-8020(13)70018-X
- PMID
- 24262192
- ISSN
- 1353-8020
- eISSN
- 1873-5126
- Language
- English
- Date published
- 01/2014
- Academic Unit
- Psychiatry; Neuroscience and Pharmacology
- Record Identifier
- 9984003479102771
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