Journal article
Aldosterone Acting Through the Central Nervous System Sensitizes Angiotensin II-Induced Hypertension
Hypertension (Dallas, Tex. 1979), Vol.60(4), pp.1023-1030
10/2012
DOI: 10.1161/HYPERTENSIONAHA.112.196576
PMID: 22949534
Abstract
Previous studies have shown that preconditioning rats with a nonpressor dose of angiotensin II (Ang II) sensitizes the pressor response produced by later treatment with a higher dose of Ang II and that Ang II and aldosterone (Aldo) can modulate each other's pressor effects through actions involving the central nervous system. The current studies tested whether Aldo can cross-sensitize the pressor actions of Ang II to enhance hypertension by employing an induction-delay-expression experimental design. Male rats were implanted for telemetered blood pressure recording. During induction, subpressor doses of either subcutaneous or intracerebroventricular Aldo were delivered for 1 week. Rats were then rested for 1 week (delay) to assure that any exogenous Aldo was metabolized. After this, Ang II was given subcutaneously for 2 weeks (expression). During induction and delay, Aldo had no sustained effect on blood pressure. However, during expression, Ang II-induced hypertension was greater in the groups receiving subcutaneous or intracerebroventricular Aldo during induction in comparison with those groups receiving vehicle. Central administration of mineralocorticoid receptor antagonist blocked sensitization. Brain tissue collected at the end of delay and expression showed increased mRNA expression of several renin-angiotensin-aldosterone system components in cardiovascular-related forebrain regions of cross-sensitized rats. Cultured subfornical organ neurons preincubated with Aldo displayed greater increases in [Ca2+]i after Ang II treatment, and there was a greater Fra-like immunoreactivity present at the end of expression in cardiovascular-related forebrain structures. Taken together, these results indicate that Aldo pretreatment cross-sensitizes the development of Ang II-induced hypertension probably by mechanisms that involve the central nervous system.
Details
- Title: Subtitle
- Aldosterone Acting Through the Central Nervous System Sensitizes Angiotensin II-Induced Hypertension
- Creators
- Baojian Xue - From the Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IAZhongming Zhang - From the Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IACamila F Roncari - From the Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IAFang Guo - From the Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IAAlan Kim Johnson - From the Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.60(4), pp.1023-1030
- DOI
- 10.1161/HYPERTENSIONAHA.112.196576
- PMID
- 22949534
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Language
- English
- Date published
- 10/2012
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health and Human Physiology
- Record Identifier
- 9984002586502771
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